Multi-omics analysis of the protective effects of Platycodon grandiflorum-derived inulin-type fructan against low-concentration PM2.5-induced lung microenvironment changes in rats
文献类型： 外文期刊
作者： Xiong, Yi 1 ; Shan, Shan 4 ; Fu, Xinjing 3 ; Zhao, Wenjie 3 ; Han, Yunlin 3 ; Xu, Yanfeng 3 ; Qu, Yajin 3 ; Sun, Xiuping 3 ; Lu, Shuwen 4 ; Guo, Jianguo 3 ; Lu, Weihong 1 ;
作者机构： 1.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China
2.Natl & Local Joint Engn Lab Synth Transformat & Se, Harbin 150001, Peoples R China
3.Chinese Acad Med Sci, Beijing Key Lab Anim Models Emerging & Remerging, Key Lab Human Dis Comparat Med, Inst Lab Anim Sci,Chinese Minist Hlt, Beijing, Peoples R China
4.Heilongjiang Acad Agr Sci, Food Proc Res Inst, Harbin 150086, Peoples R China
关键词： Platycodon grandiflorum; PM2.5 inhalation exposure; Inulin-type fructans; Protective mechanism
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 310 卷
页码：
收录情况： SCI
摘要： In northern China, haze events frequently occur during winter, and PM2.5 is recognized as the most significant particulate matter in haze, posing a major threat to human health. Therefore, we employed a PM2.5 inhalation exposure system to investigate the protective effects of Platycodon grandiflorum inulin-type fructan (PGPI-1-a) on low-concentration PM2.5-induced lung microenvironment changes. Our findings revealed that long-term (4month) PM2.5 exposure did not cause apparent pathological alterations in rat lungs but induced lung inflammation, which was alleviated by PGPI-1-a intervention. Multi-omics analysis demonstrated that PGPI-1-a restored abnormally expressed lung proteins, improved lung microbiota disorders, and regulated serum metabolite imbalances related to lipid and amino acid metabolism, ameliorating low-concentration PM2.5induced lung microenvironment changes. These results suggest that Platycodon grandiflorum inulin-type fructan could serve as a potential dietary supplement for mitigating PM2.5-induced lung injury.
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