文献类型： 外文期刊
作者： Mei, Xiuzhen 1 ; Zhang, Yuchen 1 ; Wang, Shu 1 ; Wang, Hui 2 ; Chen, Rong 2 ; Ma, Ke 2 ; Yang, Yue 2 ; Jiang, Ping 1 ; Feng, Zhixin 1 ; Zhang, Chao 6 ; Zhang, Zhenzhen 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China
3.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Peoples R China
4.Nanjing Normal Univ, Coll Marine Sci & Engn, Jiangsu Key Lab Aquat Crustacean Dis, Nanjing 210023, Peoples R China
5.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Peoples R China
6.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China
关键词： pneumonia; necroptosis; drug classification; programmed cell death
期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）
ISSN：
年卷期： 2024 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Pneumonia remains a major global health challenge, necessitating the development of effective therapeutic approaches. Recently, necroptosis, a regulated form of cell death, has garnered attention in the fields of pharmacology and immunology for its role in the pathogenesis of pneumonia. Characterized by cell death and inflammatory responses, necroptosis is a key mechanism contributing to tissue damage and immune dysregulation in various diseases, including pneumonia. This review comprehensively analyzes the role of necroptosis in pneumonia and explores potential pharmacological interventions targeting this cell death pathway. Moreover, we highlight the intricate interplay between necroptosis and immune responses in pneumonia, revealing a bidirectional relationship between necrotic cell death and inflammatory signaling. Importantly, we assess current therapeutic strategies modulating necroptosis, encompassing synthetic inhibitors, natural products, and other drugs targeting key components of the programmed necrosis pathway. The article also discusses challenges and future directions in targeting programmed necrosis for pneumonia treatment, proposing novel therapeutic strategies that combine antibiotics with necroptosis inhibitors. This review underscores the importance of understanding necroptosis in pneumonia and highlights the potential of pharmacological interventions to mitigate tissue damage and restore immune homeostasis in this devastating respiratory infection.
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