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Identification of extended-spectrum beta-lactamase (CTX-M)-producing Klebsiella pneumoniae belonging to ST37, ST290, and ST2640 in captive giant pandas

文献类型： 外文期刊

作者： Su, Xiaoyan 1 ; Yan, Xia 1 ; Li, Yunli 1 ; Zhang, Dongsheng 1 ; Li, Lin 1 ; Geng, Yi 2 ; Su, Fei 3 ; Yue, Chanjuan 1 ; Hou, Rong 1 ; Liu, Songrui 1 ;

作者机构： 1.Chengdu Res Base Giant Panda Breeding, Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu, Peoples R China

2.Sichuan Agr Univ, Coll Vet Med, Chengdu 611130, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Peoples R China

关键词： ESBL-producing Klebsiella pneumoniae; Antimicrobial resistance; Epidemiology; Giant panda

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.792； 五年影响因子：3.008 ）

ISSN：

年卷期： 2022 年 18 卷 1 期

页码：

收录情况： SCI

摘要： Background Extended-spectrum beta-lactamases (ESBL)-producing strains of Klebsiella pneumoniae remain a worldwide, critical clinical concern. However, limited information was available concerning ESBL-producing Klebsiella pneumoniae in giant pandas. The objective of this study was to characterize ESBL-producing Klebsiella pneumoniae isolates from captive giant pandas. A total of 211 Klebsiella pneumoniae isolates were collected from 108 giant pandas housed at the Chengdu Research Base of Giant Panda Breeding (CRBGP), China. Samples were screened for the ESBL-producing phenotype via the double-disk synergy test. Result A total of three (1.42%, n = 3/211) ESBL-producing Klebsiella pneumoniae strains were identified, and characterization of ESBL-producing Klebsiella pneumoniae isolates were studied by the detection of ESBL genes and mobile genetic elements (MGEs), evaluation of antimicrobial susceptibility and detection of associated resistance genes. Clonal analysis was performed by multi-locus sequencing type (MLST). Among the three ESBL-producing isolates, different ESBL-encoding genes, including bla(CTX-M), and bla(TEM,) were detected. These three isolates were found to carry MGEs genes (i.e., IS903 and tnpU) and antimicrobial resistance genes (i.e., aac(6')-Ib, aac(6')-I, qnrA, and qnrB). Furthermore, it was found that the three isolates were not hypermucoviscosity, resistant to at least 13 antibiotics and belonged to different ST types (ST37, ST290, and ST2640). Conclusion Effective surveillance and strict infection control strategies should be implemented to prevent outbreaks of ESBL-producing Klebsiella pneumoniae in giant pandas.

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