dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection
文献类型： 外文期刊
作者： Mo, Guodong 1 ; Hu, Bowen 1 ; Zhang, Qihong 1 ; Ruan, Zhuohao 1 ; Li, Wangyu 1 ; Liang, Jiaying 1 ; Shen, Yizi 1 ; Mo, Zhixin 1 ; Zhang, Zihao 1 ; Wu, Zhuyue 4 ; Shi, Meiqing 5 ; Zhang, Xiquan 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China
2.Minist Agr & Rural Affairs, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Chicken Genet, Guangzhou 510642, Guangdong, Peoples R China
4.Anim Husb Res Inst Guangxi Zhuang Autonomous Reg, Guangxi Key Lab Livestock Genet Improvement, Nanning 530005, Peoples R China
5.Univ Maryland, Virginia Maryland Reg Coll Vet Med, Div Immunol, College Pk, MD 20742 USA
关键词： early feathering chickens; late feathering chickens; immune response; ALV-J; dPRLR
期刊名称：VETERINARY RESEARCH （ 影响因子：3.829； 五年影响因子：4.269 ）
ISSN： 0928-4249
年卷期： 2022 年 53 卷 1 期
页码：
收录情况： SCI
摘要： To understand the differences in immune responses between early feathering (EF) and late feathering (LF) chickens after infection with avian leukosis virus, subgroup J (ALV-J), we monitored the levels of prolactin, growth hormone and the immunoglobulins IgG and IgM in the serum of LF and EF chickens for 8 weeks. Moreover, we analysed the expression of immune-related genes in the spleen and the expression of PRLR, SPEF2 and dPRLR in the immune organs and DF-1 cells by qRT-PCR. The results showed that ALV-J infection affected the expression of prolactin, growth hormone, IgG and IgM in the serum. Regardless of whether LF and EF chickens were infected with ALV-J, the serum levels of the two hormones and two immunoglobulins in EF chickens were higher than those in LF chickens (P < 0.05). However, the expression of immune-related genes in the spleen of positive LF chickens was higher than that in the spleen of positive EF chickens. In the four immune organs, PRLR and SPEF2 expression was also higher in LF chickens than in EF chickens. Furthermore, the dPRLR expression of positive LF chickens was higher than that of negative LF chickens. After infection with ALV-J, the expression of PRLR in DF-1 cells significantly increased. In addition, overexpression of PRLR or dPRLR in DF-1 cells promoted replication of ALV-J. These results suggested that the susceptibility of LF chickens to ALV-J might be induced by dPRLR.
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