Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice
文献类型： 外文期刊
作者： Peng, Yujia 1 ; Yan, Yamei 2 ; Wan, Peng 1 ; Chen, Dan 1 ; Ding, Yu 1 ; Ran, Linwu 3 ; Mi, Jia 2 ; Lu, Lu 2 ; Zhang, Zhijuan 2 ; Li, Xiaoying 2 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 2 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Natl Wolfberry Engn Res Ctr, Ningxia 750002, Peoples R China
3.Ningxia Med Univ, Lab Anim Ctr, Ningxia 750004, Peoples R China
关键词： Lycium ruthenicum Murray; Anthocyanins; Inflammatory bowel disease; Dextran sodium sulfate; Gut microbiota
期刊名称：FREE RADICAL BIOLOGY AND MEDICINE （ 影响因子：8.101； 五年影响因子：8.176 ）
ISSN： 0891-5849
年卷期： 2019 年 136 卷
页码：
收录情况： SCI
摘要： In the present study, the therapeutic effects of crude anthocyanins (ACN) from the fruits of Lycium ruthenicum Murray and the main monomer of ACN, petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-[beta-D-glucopyranoside] (P3G), on the dextran sodium sulfate (DSS)-induced colitis in mice were investigated. Both ACN and P3G showed intestinal anti-inflammatory effects, evidenced by restoration of various physical signs (body weight, feed quantity, solid fecal weight and colon length were increased, and DAI score was decreased), reduction of the expression of proinflammatory cytokines and related mRNA (such as TNF-alpha, IL-6, IL-1 beta and IFN-gamma), and promotion of the intestinal barrier function by histological and immunofluorescence analysis (proteins such as ZO-1, occludin and claudin-1 were increased). Furthermore, the effects on gut microbiota community of DSS-induced colitis in mice have been investigated. It was found that Porphyromonadaceae, Helicobacter, Parasutterella, Parabacteroides, Oscillibacter and Lachnospiraceae were the key bacteria associated with inflammatory bowel disease. Taken together, P3G and ACN ameliorated DSS-induced colitis in mice through three aspects including blocking proinflammatory cytokines, increasing tight junction protein and modulating gut microbiota. What's more, P3G showed better anti-inflammatory effects than ACN.
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