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Biocontrol potential of newly isolated Streptomyces noursei D337-11 from disease suppressive soil and its metabolites against Fusarium oxysporum f. sp. cubense in banana plants

文献类型： 外文期刊

作者： Zhou, Dengbo 1 ; He, Xinxin 1 ; Chen, Yufeng 1 ; Li, Chunting 1 ; Wang, Wei 1 ; Pan, Zhiqiang 2 ; Zhao, Yankun 1 ; Wei, Yongzan 1 ; Feng, Junting 1 ; Zhang, Miaoyi 1 ; Qi, Dengfeng 1 ; Li, Xiaojuan 1 ; Li, Kai 1 ; Jing, Tao 1 ; Xie, Jianghui 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Sanya Res Inst, Natl Key Lab Trop Crop Breeding, Sanya, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Sanya, Peoples R China

3.Univ Mississippi, ARS, Nat Prod Utilizat Res Unit, USDA, Oxford, MS USA

关键词： Streptomyces noursei; genome-guided differential metabolomics; banana fusarium wilt; naringenin; target protein

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN：

年卷期： 2025 年 16 卷

页码：

收录情况： SCI

摘要： Banana Fusarium wilt, caused by Fusarium oxysporum f. sp. cubense, threatens global banana production. Biocontrol using Streptomyces is a promising strategy. Here, we identified Streptomyces noursei D337-11 from disease suppressive banana soils, which exhibited dual functionality in controlling F. oxysporum f. sp. cubense tropical race 4 (Foc TR4), achieving a 65.35% suppression of disease, and promoting plant growth in pot experiments. The extracts from this strain restored the soil microbiota disrupted by Foc TR4, particularly, reviving Saccharimonadales populations. Using integrated untargeted metabolomics (LC-ESIMS/MS) and genomic analysis, we identified five bioactive metabolites, including naringenin, a flavonoid linked to a 100% homologous biosynthetic gene cluster (Region 52.1). Genome-guided differential metabolomics established the genetic basis for flavonoid production. Mechanistic characterization indicated that naringenin exhibits antifungal activity via dual-target inhibition: molecular docking showed strong binding to the trypsin of Foc TR4 (N1RZA7, -6.6 kcal/mol) and nitroalkane oxidase (N1R9V2, -8.4 kcal/mol), which disrupts cellular integrity as evidenced by ultrastructural anomalies. We provide the first evidence of Streptomyces-derived naringenin as a multi-target antifungal agent. Overall, this study provides a theoretical basis for exploring the application of microbial flavonoids in biological control of fungal diseases.

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