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Autologous platelet-rich fibrin enhances skin wound healing in a feline trauma model

文献类型： 外文期刊

作者： Zhang, Shuai 1 ; Tan, Haoyang 1 ; Cheng, Xin 1 ; Dou, Xinyi 1 ; Fang, Hao 3 ; Zhang, Cuihong 6 ; Yang, Guiyan 2 ; Yang, Haotian 1 ; Zhao, Yuan 1 ; Feng, Tongtong 1 ; Fan, Honggang 1 ; Sha, Wanli 1 ;

作者机构： 1.Northeast Agr Univ, Coll Vet Med, Harbin, Peoples R China

2.China Agr Univ, Coll Vet Med, Beijing, Peoples R China

3.Chongqing Univ, Coll Optoelect Engn, Chongqing, Peoples R China

4.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar, Peoples R China

5.Jilin Agr Sci & Technol Univ, Coll Anim Sci & Technol, Jilin 132109, Peoples R China

6.Guangzhou Med Univ, Hui Zhou Peoples Hosp 3, Guangzhou, Peoples R China

关键词： Autologous platelet-rich fibrin; Trauma; Skin; Cat; Inflammation

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.7 ）

ISSN：

年卷期： 2024 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Trauma is a common cause of cutaneous surgical disease with an increased risk of secondary infection in cat clinics. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing multiple cytokines and growth factors, is known to accelerate the healing of wounds. However, how PRF affects wound healing in the cat trauma model has not been fully investigated. The study aimed to examine the impact of PRF on skin wound healing in the cat trauma model. In this study, PRF from cats was successfully produced for our investigation. The models of feline trauma were effectively established. A total of 18 cats were randomly divided into 3 groups (n = 6): (1) Control group (CON); (2) PRF group; (3) Manuka honey group (MAN, as a positive control). Experiments were performed separately on days 7, 14, 21, and 28. Our results showed that PRF was a safe and efficient method of wound healing that did not influence the cat's body temperature, respiration rate, and heart rate (HR). PRF accelerated skin wound healing in the cat trauma model based on the rate and histological observation of wound healing. In addition, PRF promoted the production of growth factors and suppressed inflammation during wound healing. PRF accelerated wound healing by increasing the formation of collagen fibers, as shown by Masson-trichrome staining. The outcomes of the PRF and MAN groups were comparable. In conclusion, PRF improves the healing of skin wounds in cats by boosting the synthesis of growth factors, reducing inflammation, and enhancing the synthesis of collagen fibers.

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