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Combined Toxicity Assessment of Deoxynivalenol and Pb2+ on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis

文献类型： 外文期刊

作者： Zhu, Zuoyin 1 ; Wang, Jie 1 ; Cheng, Haisheng 1 ; Zhao, Hanke 2 ; Liu, Chengbin 2 ; Zhou, Xinli 1 ; Yang, Junhua 2 ;

作者机构： 1.Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China

2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Shanghai 201403, Peoples R China

关键词： ferroptosis; combined toxicity; mycotoxins; heavy metals

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 4 期

页码：

收录情况： SCI

摘要： The cocontamination of food by several mycotoxins and heavy metals poses significant health risks, and their combined toxic effects remain poorly understood. Particularly, specific studies exploring their combined impact on ferroptosis remain limited. In this work, we investigated the combined toxic effects of a mycotoxin, called deoxynivalenol (DON), and a heavy metal, called plumbum (Pb), and explored the potential mechanisms of DON and Pb co-occurrence via excessive ROS-induced ferroptosis in HK-2 cells. It was found that combined toxicity of DON and Pb2+ showed a synergism at low concentrations and an antagonism at high concentrations. The increase of the ROS level and iron content as well as the change expression of four ferroptosis marker proteins were observed in DON and Pb2+ individual and combined groups. Furthermore, the addition of ferroptosis inhibitor Fer-1 could mitigate the imbalance of oxidative stress and ferroptosis. Our results suggest that the co-occurrence of DON and Pb2+ might pose a slight threat to the nephrotoxicity due to the interactions related to the excessive ROS-induced ferroptosis, which would provide valuable insights into their potential combined toxic impacts to human and animal health.

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