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Rapid Measurement of Residual Kanamycin Using Highly Specific Biomimetic Recognition Paper-Based Chip

文献类型: 外文期刊

作者: Song, Jian 1 ; He, Kaiyu 2 ; Xing, Bingcong 1 ; Pei, Yong 4 ; Wang, Dingnan 3 ; Wang, Yang 5 ; Li, Shiyan 5 ; Li, Jie 6 ; Huan, Weiwei 6 ; Zhang, Yiming 1 ; Hammock, Bruce. D. 7 ;

作者机构: 1.Zhejiang A&F Univ, Coll Food & Hlth, Hangzhou 311300, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Informat Traceabil Agr Prod,Minist Agr & R, Hangzhou 310021, Peoples R China

3.Zhejiang A&F Univ, Zhejiang Prov Key Lab Resources Protect & Innovat, Hangzhou 311300, Peoples R China

4.Xiangtan Univ, Dept Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan 411105, Peoples R China

5.Inst Zhejiang Aquat Prod Technol, Hangzhou 310000, Peoples R China

6.Zhejiang A&F Univ, Coll Chem & Mat Engn, Zhejiang Prov Key Lab Chem Utilizat Forestry Bioma, Hangzhou 311300, Peoples R China

7.Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA

8.Univ Calif Davis, UCD Comprehens Canc Ctr, Dept Entomol, Davis, CA 95616 USA

期刊名称:ANALYTICAL CHEMISTRY ( 影响因子:8.008; 五年影响因子:7.528 )

ISSN: 0003-2700

年卷期:

页码:

收录情况: SCI

摘要: The development of highly specific biomimetic recognition material is a challenge for rapid detection of harmful residues in foodstuff. In this study, a paper-based boronate affinity metal-organic framework/molecularly imprinted polymer microfluidic chip (FZS-BA@MIP) was constructed based on the in situ construction strategy, which was also designed as a highly specific biomimetic recognition module. Here, the homogeneous zeolitic imidazole framework-8 (ZIF-8) membrane served as a great scaffold and enrichment layer. Besides, the recognition layer of MIP was prepared based on a highly oriented boronate affinity surface imprinting strategy. With the aid of the liquid flow channel, the highly specific enrichment and visual detection for antibiotic residues like kanamycin in actual products were achieved on the paper chip module of an integrated lateral flow platform. The whole analysis process could be accomplished within 30 min. In brief, this study offered a new integrated biomimetic recognition platform for visually detecting harmful veterinary residues containing cis-diols, which demonstrated promising commercial value in point-of-care testing of foodborne hazardous compounds.

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