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Identification of key phenolic compounds for alleviating gouty inflammation in edible chrysanthemums based on spectrum-effect relationship analyses

文献类型： 外文期刊

作者： Huang, Yuting 1 ; Tao, Mingfang 1 ; Li, Rong 1 ; Liang, Fuqiang 4 ; Xu, Tingting 1 ; Zhong, Qiang 1 ; Yuan, Yanan 1 ; Wu, Ting 1 ; Pan, Siyi 1 ; Xu, Xiaoyun 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Hubei Key Lab Fruit & Vegetable Proc & Qual Contro, Key Lab Environm Correlat Dietol,Minist Educ, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Detect Technol, Hubei Key Lab Nutr Qual & Safety Agroprod, Wuhan 430064, Peoples R China

3.Jingchu Univ Technol, Res Inst Agr Biotechnol, Jingmen 448000, Peoples R China

4.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Nanjing 210023, Peoples R China

关键词： Chrysanthemum morifolium Ramat.; Gout; Inflammation; Phenolics; Spectrum-effect relationship

期刊名称：FOOD CHEMISTRY-X （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 2590-1575

年卷期： 2023 年 20 卷

页码：

收录情况： SCI

摘要： Edible chrysanthemum is a common food resource for tea and functional foods with potential benefits for human health. Studies have indicated that chrysanthemum has the potential effect on inflammatory diseases, while the effects on gouty inflammation remain underexplored. The present study aimed to investigate the anti-gout activity and characterize the active ingredients of chrysanthemums by using metabolite profiles, in vitro experiments, and spectrum-effect analysis. Results showed that 'Boju' (BJ), 'Hangbaiju' (HBJ), and 'Huaiju' (HJ) exhibited regulatory effects on monosodium urate (MSU)-induced inflammation. At the dose of 50 mu g/mL, the inhibitory rates of IL-1 beta secretion were 24.53 %, 14.36 %, and 38.10 %, respectively. A total of 32 phenolic compounds were identified or preliminarily assigned in UPLC-Q/TOF-MS analysis. And seven phenolics related to anti-gout activity were identified by spectrum-effect relationships. According to ADME (absorption, distribution, metabolism, excretion) evaluation and experiments verification, luteolin, acacetin-7-O-glucoside, and apigenin-7-O-glucoside were critical constituents potentially associated with the reduction of inflammation in gout. Additionally, these phenolics might be suitable as quality control indicators. This study clarified the antigout properties of different cultivars of chrysanthemums and active compounds, providing a theoretical basis for its scientific utilization in functional foods.

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