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Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium

文献类型: 外文期刊

作者: Liu, X. -J. 1 ; Luo, Z. 1 ; Li, C. -H. 2 ; Xiong, B. -X. 1 ; Zhao, Y. -H. 3 ; Li, X. -D. 3 ;

作者机构: 1.Huazhong Agr Univ, Fishery Coll, Wuhan 430070, Peoples R China

2.CAFS, S China Sea Fisheries Res Inst, Minist Agr, Key Lab Mariculture Ecol & Qual Control, Guangzhou 510300, Guangdong, Peoples R China

3.Panjin Guanghe Fishery Co Ltd, Postgrad Res Base, Panjin 124200, Peoples R China

关键词: cadmium toxicity;synechogobius hasta;antioxidant responses;histology;ultrastructure;hepatic intermediary metabolism;fatty liver syndrome

期刊名称:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY ( 影响因子:6.291; 五年影响因子:6.393 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The present study was conducted to determine antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta after a 15-days of waterborne cadmium (Cd) exposure at the concentrations of 0 (control), 0.10, 0.17 and 0.29 mg Cd/1 (corresponding to 0, 12.6%, 21.5% and 36.7% of 96 h LC_(50)), respectively. Growth performance and survival declined, but hepatoso-matic index (HSI) increased with increasing waterborne Cd levels (P< 0.05). Waterborne Cd exposure also significantly increased lipid contents in whole body and liver (P< 0.05), and Cd accumulation in whole body, muscle and vertebrae. Waterborne Cd exposure changed hepatic enzymatic activities involved in intermediary metabolism, induced antioxidant responses and increased lipid peroxidation level in the gill, liver and spleen. Waterborne Cd exposure also caused considerable histological alterations of gill, liver and spleen, led ultrastructures damage of liver and spleen of fish, and induced fatty liver for this fish species.

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