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Synthesis and Insecticidal Activities of Novel Spin-Labeled Derivatives of Camptothecin

文献类型： 外文期刊

作者： Liu, Ying-Qian 1 ; Dai, Wei 1 ; Tian, Jing 1 ; Yang, Liu 2 ; Feng, Gang 3 ; Zhou, Xing-Wen 1 ; Kou, Liang 1 ; Zhao, Yong- 1 ;

作者机构： 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

2.Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China

3.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Danzhou 571737, Peoples R China

期刊名称：HETEROATOM CHEMISTRY （ 影响因子：1.366； 五年影响因子：1.162 ）

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收录情况： SCI

摘要： Continuing our search for natural product based compounds for the control of Brontispa longissima larvae, eight spin-labeled camptothecin derivatives 7a-h and the intermediate 2 were first tested for their insecticidal activities against fifth-instar larvae of Brontispa longissima. Among all the tested compounds, especially compounds 7a and 2 showed promising insecticidal activities with the corrected mortality rates of 69.55% and 74.07% against fifth-instar larvae of B. longissima, respectively. The different insecticidal activity ranges of these compounds indicated that the variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.

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