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Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom

文献类型： 外文期刊

作者： Li, Ning 2 ; Li, Le 3 ; Fang, Jin Cen; Wong, Jack Ho 1 ; Ng, Tzi Bun 1 ; Jiang, Yun 2 ; Wang, Chang Rong 2 ; Zhang, Ni 1 ;

作者机构： 1.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China

2.Nankai Univ, Coll Life Sci, Dept Microbiol, Tianjin 300071, Peoples R China

3.Chinese

关键词： Biological activity;Pleurotus abalonus (abalone mushroom);Polysaccharide-peptide complex;Structural characterization

期刊名称：BIOSCIENCE REPORTS （ 影响因子：3.84； 五年影响因子：4.059 ）

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收录情况： SCI

摘要： A novel antioxidant polysaccharide-peptide complex LB-1b from the fruiting bodies of the edible abalone mushroom (Pleurotus abalonus) was purified and identified. The structural characteristic of LB-1b was identified by FTIR (Fouriertransform IR), ~(13)C NMR and ~1H NMR spectroscopy. LB-1b is a polysaccharide-peptide complex that contains glucose, rhamnose, glucuronic acid and galactose in the molar ratio of 22.4:1:1.7:1.6 and the N-terminal sequence of its peptide moiety has also been determined. The N-terminal amino acid sequence of LB-1b, IPKERKEFQQAQHLK, showed some resemblance to antioxidant enzymes. LB-1b exhibited high antioxidant activity in erythrocyte haemolysis in vitro and the anti-proliferative activity towards hepatoma HepG2 cells and breast cancer MCF7 cells with an IC _(50) of 24 and 14 μM respectively. LB-1b also demonstrated hypoglycaemic activity in drug-induced diabetic mice and anti-HIV-1 RT (reverse transcriptase) with an IC _(50) value of 12.5 μM.

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