Antidiabetic Activities of Ethanol Extract of Dry Matters of Culture Broth of Coriolus versiolor in Submerged Culture
文献类型： 外文期刊
作者： Zhang, Zuofa 1 ; Lv, Guoying 1 ; Pan, Huijuan 1 ; dos Santos, Leandro Freire 2 ; Fan, Menghai 3 ; Soccol, Carlos Ri 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou 310021, Zhejiang, Peoples R China
2.Univ Fed Parana, Dept Engn Bioproc & Biotecnol, BR-80060000 Curitiba, Parana, Brazil
3.Hangzhou Verdade Biotech Co Ltd, Hangzhou 310054, Zhejiang, Peoples R China
4.Univ Positivo, Curitiba, Parana, Brazil
关键词： Coriolus versiolor;Antihyperglycemic;Antilipidperoxidative;Diabetes
期刊名称：BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY （ 影响因子：0.797； 五年影响因子：1.193 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： The study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein -cholesterol (HDL-C) in serum and reduced glutathione level (GSH), lipid peroxidation, glycogen, antioxidant enzymes in liver were evaluated. Moreover, histopathological observation was conducted. Streptozotocin treatment (150 mg/kg body weight) induced the decrease of GSH level, antioxidant enzymes activities, glycogen content in liver, HDL-C content and insulin level in serum, accompanied bythe elevation of the lipid peroxidation in liver, serum blood glucose level, contents of TC, TG and LDL-C. Treatment with ECBC restored the changes in the above parameters up to the basal level. The protective effects were further supported by the attenuation of the degree of pancreas damage in ECBC treated mice.
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