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Ribavirin, a nucleoside with potential insecticidal activity

文献类型: 外文期刊

作者: Liu, Ying-Qian 1 ; Zhang, Jing 2 ; Feng, Gang 2 ; Li, Lin-Hai 1 ; Yang, Liu 3 ; Kou, Liang 1 ;

作者机构: 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Danzhou, Peoples R China

3.Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730070, Peoples R China

关键词: ribavirin;Spodoptera litura;food intake;larval growth;insecticidal activity

期刊名称:PEST MANAGEMENT SCIENCE ( 影响因子:4.845; 五年影响因子:4.674 )

ISSN:

年卷期:

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收录情况: SCI

摘要: BACKGROUND: The triazole-based antiviral nucleoside ribavirin exhibited significant in vitro insecticidal effects against Spodoptera litura, a finding that has prompted further investigations into its in vivo insecticidal properties and mode of action against this insect pest.RESULTS: Ribavirin showed delayed insecticidal effects on third-instar larvae of 5. litura at a concentration of 1 mg mL~(-1). When incorporated into an artificial diet, ribavirin caused various effects, depending on the concentration used. Compared with controls, food intake was lower, larval growth was reduced and larval development prolonged. Pupae weight was reduced, and adult morphology was also affected. Relative to the untreated group, treated groups showed higher mortality at larval and pupal stages, which was generally caused by moult disruption. Results of this study with ribavirin resemble those found in treatment with insect growth regulators.CONCLUSION: This work shows that ribavirin merits further study as a lead compound in a novel class of potential insect control agents or for managing field populations of Lepidoptera pests on cruciferous crops.

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