Intranasal immunisation with Stx2B-Tir-Stx1B-Zot protein leads to decreased shedding in goats after challenge with Escherichia coli O157:H7
文献类型： 外文期刊
作者： Zhang, X-H. 1 ; He, K-W. 1 ; Zhao, P-D. 1 ; Ye, Q. 1 ; Luan, X-T. 1 ; Yu, Z-Y. 1 ; Wen, L-B. 1 ; Ni, Y-X. 2 ; Li, B.; Wang, 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Key Lab Engn Res Vet Bioprod, Natl Ctr Engn Res Vet Bioprod, Agr Minist,Inst Vet Med, Nanjing 210014, Peoples R China
2.Jiangsu Acad Agr Sci, Key Lab Engn Re
期刊名称：VETERINARY RECORD （ 影响因子：2.695； 五年影响因子：2.797 ）
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收录情况： SCI
摘要： Other than cattle, small domestic ruminants (sheep and goats) have been found to be an important reservoir of Escherichia coli 0157-H7. Reducing E coli O157-.H7 excretion by these animals could play a key role in the prevention and control of human infections. The aim of this study was to determine whether vaccination of goats with a recombinant Stx2B-Tir-StxlB-Zot protein was capable of reducing faecal shedding of E coli O157:H7 in an oral infection model.
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