您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

In vitro antiviral activity of sulfated Auricularia auricula polysaccharides

文献类型： 外文期刊

作者： The Luong Nguyen 1 ; Chen, Jin; Hu, Yuanliang 1 ; Wang, Deyun 1 ; Fan, Yunpeng 1 ; Wang, Junmin 1 ; Abula, Saifudin 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R C

关键词： Sulfated Auricularia auricula polysaccharide;Newcastle disease virus;Cellular infectivity

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Total Auricularia auricula polysaccharide (AAP_t) was prepared by extracting and removing the proteins. Column chromatography was used to further graded it into AAP1 and AAP2. Three AAPs were modified by chlorosulfonic acid-pyridine method to obtain three sulfated AAPs (sAAPs), sAAP_t, sAAP1 and SAAP2, respectively. Three sAAPs and Newcastle disease virus (NDV) were added into cultivation system of chicken embryo fibroblast (CEF) in three manners, pre-, post- and simultaneous-adding polysaccharide with NDV respectively, taking three non-modified AAPs as control. Their anti-viral activities were compared by MTT method. The results showed that sAAPs and AAPs at a certain concentration could significantly inhibit the cellular infectivity of NDV in three manners. The effects of sAAPs were better than that of AAPs. It indicated that sulfated modification could enhance the antiviral activity of AAP. sAAP1 and sAAP_t possessed stronger activity and would be as the component of a new-type antiviral drug.

  • 相关文献

[1]Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells. Meng, Gang,Xia, Mao,Wang, Diancheng,Chen, Aiping,Wang, Hongwei,Yu, Decai,Wei, Jiwu,Yu, Decai,Wei, Jiwu,Wang, Yongshan. 2014

[2]Antiviral activity of rChIFN-alpha against vesicular stomatitis virus and Newcastle disease virus: A novel recombinant chicken interferon-alpha showed high antiviral activity. Hou, Fengxiang,Liu, Ke,Shen, Ting,Zhou, Bin,Cao, Ruibin,Li, Peide,Chen, Puyan,Hou, Fengxiang. 2011

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台