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Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide

文献类型： 外文期刊

作者： Zhang, Jing 1 ; Chen, Jin 2 ; Wang, Deyun 1 ; Hu, Yuanliang 1 ; Zhang, Cunshuai 3 ; Qin, Tao 1 ; Liu, Cui 1 ; Sheng, Xin; 1 ;

作者机构： 1.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R China

3.China Inst Vet Drug Control, Beijing 100081, Peoples R China

关键词： Lymphocytes proliferation;Serum antibody titer;Sulfated jujube polysaccharides;Sulfated ophiopogonpolysaccharides

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： The immune-enhancing activities of four sulfated polysaccharides, sOPS_t, sOPS_(80), sJPS_t and sJPS_(50) picked out in our previous researches, were compared taking four corresponding unmodified polysaccharides as control. In vitro experiment, the effects of eight polysaccharides on chicken peripheral lymphocyte proliferation were determined by MTT assay. The result displayed that four sulfated polysaccharides could significantly stimulate lymphocyte proliferation, their actions were significantly or numerically stronger than those of corresponding unmodified polysaccharides, sOPS_(80) presented better efficacy. In vivo experiment, 300 14-day-old chickens were averagely divided into ten groups. The chickens except blank control (BC) group were vaccinated with Newcastle disease vaccine, repeated vaccination at 28 days old. At the same time of the first vaccination, the chickens in eight polysaccharides groups were injected respectively with 0.5ml (1mg) of eight polysaccharides, in vaccination control (VC) and BC group, with 0.5mL of physiological saline, once a day for three successive days. On days 7, 14, 21 and 28 after the first vaccination, the peripheral lymphocyte proliferation and serum ND antibody titer were determined. The result showed that four sulfated polysaccharides could significantly promote lymphocyte proliferation and enhance serum antibody titer. Their actions were significantly or numerically stronger than those of corresponding unmodified polysaccharides, sOPS_(80) possessed the best efficacy. These results indicated that sulfation modification could enhance the immune-enhancing activity of OPS and JPS, sOPS_(80) possessed the best efficacy and would be expected as a component drug of new-type immunopotentiator.

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