您好,欢迎访问中国热带农业科学院 机构知识库!

Synthesis and Quantitative Structure-Activity Relationship (QSAR) Study of Novel 4-Acyloxypodophyllotoxin Derivatives Modified in the A and C Rings as Insecticidal Agents

文献类型: 外文期刊

作者: He, Shuzhen 1 ; Shao, Yonghua 2 ; Fan, Lingling 1 ; Che, Zhiping 1 ; Xu, Hui 1 ; Zhi, Xiaoyan 1 ; Wang, Juanjuan 1 ; Yao, 1 ;

作者机构: 1.NW A&F Univ, Coll Sci, Lab Pharmaceut Design & Synth, Yangling 712100, Shannxi Provinc, Peoples R China

2.Lanzhou Univ, Dept Chem, Lanzhou 730000, Gansu, Peoples R China

3.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Hainan Province, Peoples R China

关键词: podophyllotoxin;acyloxy;A and C ring modification;botanical insecticide;insecticidal activity;QSAR;Mythimna separata Walker

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum. Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure—activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R~2) is 0.914, the leave-one-out cross-validation correlation coefficient (Q_(Loo)~2) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Morl4v, Wap, Glv, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Morl4v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.

  • 相关文献

[1]Podophyllotoxin-derived insecticidal agents: Part XIII - Evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima. Liu, Ying-Qian,Li, Hong-Yu,Liu, Ying-Qian,Li, Hong-Yu,Feng, Gang,Jing-Zhang,Yang, Liu. 2011

[2]Design, semisynthesis and insecticidal activity of novel podophyllotoxin derivatives against Brontispa longissima in vivo. Liu, Ying-Qian,Zhao, Yong-Long,Zhou, Xing-Wen,Yang, Liu,Feng, Gang. 2012

[3]Podophyllotoxin derivatives show activity against Brontispa longissima larvae. Liu, Ying-Qian,Zhang, Jing,Feng, Gang,Yang, Liu.

[4]A strategy on the definition of applicability domain of model based on population analysis. Yun, Yong-Huan,Wu, Dong-Ming,Li, Guang-Yi,Zhang, Qiao-Yan,Yang, Xia,Li, Qin-Fen,Yun, Yong-Huan,Wu, Dong-Ming,Li, Guang-Yi,Li, Qin-Fen,Cao, Dong-Sheng,Xu, Qing-Song.

[5]Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae. Feng, Gang,Zhang, Jing,Jin, Qi-An,Peng, Zheng-Qiang,Liu, Ying-Qian,Zhang, Zhi-Wei,Yang, Liu,Tian, Xuan.

[6]Khayasin and 2 ' S-methylbutanoylproceranolide: Promising candidate insecticides for the control of the coconut leaf beetle, Brontispa longissima. Li, Min-Yi,Wu, Jun,Zhang, Jing,Feng, Gang,Li, Min-Yi,Satyanandamurty, Tirumani. 2011

[7]Design, synthesis and bioactivity evaluation of novel acylthiourea derivatives of cantharidin. Wang, Mei-Juan,Nan, Xiang,Liu, Ying-Qian,Yu, Hai-Tao,Hu, Guan-Fang,Feng, Gang. 2014

[8]Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island. Guo, Zhikai,Gai, Cuijuan,Cai, Caihong,Chen, Liangliang,Liu, Shoubai,Zeng, Yanbo,Yuan, Jingzhe,Mei, Wenli,Dai, Haofu,Guo, Zhikai,Gai, Cuijuan,Cai, Caihong,Chen, Liangliang,Liu, Shoubai,Zeng, Yanbo,Yuan, Jingzhe,Mei, Wenli,Dai, Haofu. 2017

[9]Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima. Yang, Liu,Zhang, Zhi-Jun,Liu, Ying-Qian,Zhao, Chun-Yan,Wang, Mei-Juan,Nan, Xiang,Feng, Gang.

[10]Ribavirin, a nucleoside with potential insecticidal activity. Liu, Ying-Qian,Li, Lin-Hai,Kou, Liang,Zhang, Jing,Feng, Gang,Yang, Liu.

作者其他论文 更多>>