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Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae

文献类型： 外文期刊

作者： Feng, Gang 1 ; Zhang, Jing 1 ; Yang, Liu 3 ; Liu, Ying-Qian 2 ; Zhang, Zhi-Wei 2 ; Tian, Xuan 4 ; Jin, Qi-An 1 ; Peng, Zh 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Integrated Pest Management Trop Crops, Environm & Plant Protect Inst, Minist Agr, Danzhou 571737, Peoples R China

2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

3.Lanzhou Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China

4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

关键词： Brontispa longissima;Insect antifeedants;Podophyllotoxin;Spin-labeled

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： To continue our search for natural product-based compounds for the control of Brontispa longissima larvae, eight spin-labeled podophyllotoxin derivatives (4a-h) and the intermediates 2 and 3 were tested for their insect antifeedant activity against third-instar larvae of B. longissima. Among all the tested compounds, 4a, 4c, 2 and 3 showed pronounced antifeedant activities with AFC_(50) values of 0.16, 0.31, 0.15 and 0.28 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.

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