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Notch1-mediated signaling regulates proliferation of porcine satellite cells (PSCs)

文献类型： 外文期刊

作者： Qin, Lili 1 ; Xu, Jian 1 ; Wu, Zhenfang 1 ; Zhang, Zhe 1 ; Li, Jiaqi 1 ; Wang, Chong 1 ; Long, Qiaoming 2 ;

作者机构： 1.S China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

2.Cornell Univ, Dept Anim Sci, Coll Agr & Life Sci, Ithaca, NY 14850 USA

关键词： Cell cycle regulators;GSK3β-3;Myogenic progenitor;Notch;Porcine satellite cell;RhNF-κB-induced

期刊名称：CELLULAR SIGNALLING （ 影响因子：4.315； 五年影响因子：4.206 ）

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收录情况： SCI

摘要： Notch signaling is an evolutionarily conserved cell-cell communication mechanism involved in the regulation of cell proliferation, differentiation and fate decisions of mammalian cells. In the present study, we investigated the possible requirement for Notch signaling in the proliferation and differentiation of porcine satellite cells. We show that Notch1, 2 and 3 are expressed in cultured porcine satellite cells. Knock-down of NOTCH1, but not NOTCH2 and NOTCH3, decreases the proliferation of porcine satellite cells. In contrast, enhancement of NOTCH1 expression via treatment of porcine satellite cells with recombinant NF-κB increases the proliferation of porcine satellite cells. The alteration of porcine satellite cell proliferation is associated with significant changes in the expression of cell cycle related genes (cyclin B1, D1, D2, E1 and p21), myogenic regulatory factors (MyoD and myogenin) and the Notch effector Hes5. In addition, alteration of Notch1 expression in porcine satellite cells causes changes in the expression of GSK3β-3. Taken together, these findings suggest that of the four notch-related genes, Notch1is likely to be required for regulating the proliferation and therefore the maintenance of porcine satellite cells in vivo, and do so through activation of the Notch effector gene Hes5.

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