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Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide

文献类型： 外文期刊

作者： Qin, Tao 1 ; Chen, Jin; Wang, Deyun 1 ; Hu, Yuanliang 1 ; Zhang, Jing 1 ; Wang, Mi 1 ; Qiu, Shulei 1 ; Gao, Zhenzhen 1 ;

作者机构： 1.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R C

关键词： Selenizing Chinese angelica polysaccharide;(sCAP);Lymphocyte proliferation;Antibody titer;IFN-γ;IL-6

期刊名称：CARBOHYDRATE POLYMERS （ 2020影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

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收录情况： SCI

摘要： On the basis of previous test that selenizing Chinese angelica polysaccharides (sCAPs) with stronger immune-enhancing activity in vitro were picked out, the immune-enhancing activity in vivo of three sCAPs, sCAP2, sCAP6 and sCAP8, at high and low dosage were compared taking the unmodified Chinese angelica polysaccharide (CAP) as control by determination of peripheral lymphocyte proliferation, serum antibody titer, IFN-γ and 1L-6 contents in chicken vaccinated with Newcastle Disease vaccine. The results showed that three sCAPs at suitable dosage could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-γ and IL-6 contents as compared with unmodified CAP, SCAP2 at low dosage possessed the strongest action. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CAP, sCAP2 possessed the best efficacy and would be as a component drug of new-type immunoenhancer.

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