Preparation of a novel carboxyl stationary phase by "thiol-ene" click chemistry for hydrophilic interaction chromatography
文献类型： 外文期刊
作者： Peng, Xi-Tian 1 ; Liu, Tao 1 ; Ji, Shu-Xian 1 ; Feng, Yu-Qi 1 ;
作者机构： 1.Wuhan Univ, Minist Educ, Key Lab Analyt Chem Biol & Med, Dept Chem, Wuhan 430072, Peoples R China
2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol Res, Wuhan, Peoples R China
关键词： Click chemistry;hydrophilic interaction chromatography;nucleosides;retention mechanisms;water-soluble vitamins
期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）
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收录情况： SCI
摘要： A novel carboxyl-bonded silica stationary phase was prepared by "thiol-ene" click chemistry. The resultant Thiol-Click-COOH phase was evaluated under hydrophilic interaction liquid chromatography (HILIC) mobile phase conditions. A comparison of the chromatographic performance of Thiol-Click-COOH and pure silica columns was performed according to the retention behaviors of analytes and the charged state of the stationary phases. The results indicated that the newly developed Thiol-Click-COOH column has a higher surface charge and stronger hydrophilicity than the pure silica column. Furthermore, the chromatographic behaviors of five nucleosides on the Thiol-Click-COOH phase were investigated in detail. Finally, a good separation of 13 nucleosides and bases, and four water-soluble vitamins was achieved.
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