文献类型： 外文期刊
作者： Zhu, Yu-Jing 1 ; Pan, Zhi-Zhen 1 ; Yu, Xiao-Jie 2 ; Li, Zhi-Cong 2 ; Su, Ming-Xing 1 ; Huang, Jian-Zhong 3 ; Wu, Song- 1 ;
作者机构： 1.Fujian Acad Agr Sci, Agr Bioresources Inst, Fuzhou 350003, Peoples R China
2.Xiamen Univ, Sch Life Sci, Coll Environm & Ecol, Key Lab,Minist Educ Coastal & Wetland Ecosyst, Xiamen 361005, Peoples R China
3.Fujian Normal Univ, Minist Educ, Engn Res Ctr Ind Microbiol, Fuzhou 350108, Peoples R China
关键词： Griseofulvin;Antifungal activity;Greenhouse test;Analogues;Solubility comparison.
期刊名称：ASIAN JOURNAL OF CHEMISTRY （ 影响因子：0.355； 五年影响因子：0.293 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： The antifungal activity of griseofulvin was evaluated against phytopathogenic fungi including Fusarium moniliforme, Fusarium solani, Fusarium oxysporum and Colletotrichum truncatum. The greenhouse test was also made to evaluate the control efficiency of griseofulvin to eggplant powdery mildew. The results indicated griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test. Subsequently, five griseofulvin analogues were synthesized and evaluated for antifungal activities against the four fungi. The results showed that these compounds performed significantly different activities in comparison with griseofulvin. The inhibition mechanism and bioavailability of active analogues were taken to expound their different performance and relations of structure and activity. The solubility in different solvents of analogues and griseofulvin was roughly evaluated and compared.
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