文献类型： 外文期刊

作者： Rao, You S. ¹ ; Wang, Zhang F. ¹ ; Chai, Xue W. ¹ ; Nie, Qing H. ² ; Zhang, Xi Q. ² ;

作者机构： 1.Nanchang Normal Univ, Dept Biol Technol, Nanchang, Jiangxi, Peoples R China

2.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Guangdong, Peoples R China

关键词： Gallus gallus;5′ UTR length;Gene expression pattern;Selection

期刊名称：GENETICA （ 影响因子：1.082； 五年影响因子：1.489 ）

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收录情况： SCI

摘要： The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and non-amniote vertebrates. Here, we carried out a systematic study of the relationship between 5' UTR length and gene expression pattern in the chicken genome. We found that gene 5' UTRs lengths show a negative correlation with gene expression levels and gene expression breadths significantly. The relevance of 5' UTR length to expression pattern can not be a consequence of transcription-associated mutations. We also found that gene 5' UTR length shows a weakly positive correlation with gene tissue specificity. Another intriguing finding is that genes with 5' UTR length < 30 bp have highest expression level, highest expression breadth, and lowest tissue specificity in chicken. We argued that selection is likely involved in shaping 5' UTR length in the chicken genome.