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In Vitro Protective Efficacy of Clostridium butyricum Against Fish Pathogen Infections

文献类型: 外文期刊

作者: Gao, Quanxin 1 ; Xiao, Yingping 2 ; Sun, Peng 1 ; Peng, Shiming 1 ; Yin, Fei 1 ; Ma, Xiangming 3 ; Shi, Zhaohong 1 ;

作者机构: 1.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Minist Agr, Key Lab Marine & Estuarine Fisheries, Shanghai 200090, Peoples R China

2.Zhejiang Univ, Coll Anim Sci, Hangzhou 310000, Zhejiang, Peoples R China

3.China Univ Petr, Natl Univ Sci Pk Management Comm, Dongying 257091, Peoples R China

关键词: Adhesion;Apoptosis;Clostridium butyricum;Fish;Salmonella enteritidis;Vibrio parahaemolyticus

期刊名称:INDIAN JOURNAL OF MICROBIOLOGY ( 影响因子:2.461; 五年影响因子:2.259 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Most pathogens in intestine are opportunist, called "opportunistic pathogens" that usually do not cause disease in a healthy host. Only when the host's resistance is lowered or the intestinal microecological balance is destroyed, the opportunistic pathogens are capable of causing disease. Here, two opportunistic pathogens, Salmonella enteritidis and Vibrio parahaemolyticus were chosen to test the possible antagonistic effect of the probiotic agent Clostridium butyricum on these pathogens infections in vitro using fish intestinal epithelial cells (FIECs). The C. butyricum and its spent culture supernatants exhibited significant inhibitory activity on S. enteritidis and V. parahaemolyticus growth and adherence to FIECs. The C. butyricum also showed significant inhibitory effects on S. enteritidis and V. parahaemolyticus induced apoptosis, which may due to its growth and adhesion inhibitory effects. These results indicated that the probiotic bacterium C. butyricum has preventive and therapeutic effects on S. enteritidis and V. parahaemolyticus infections in fish.

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