文献类型： 外文期刊
作者： Luo, Hui 1 ; Yang, Shengjie 2 ; Zhao, Qi 3 ; Xiang, Hongmei 3 ;
作者机构： 1.Guizhou Acad Agr Sci, Guizhou Fruit Inst, Guiyang 550006, Peoples R China
2.Yangtze River Pharmaceut Grp Co Ltd, Res Inst Tradit Chinese Med, Taizhou 225321, Peoples R China
3.Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China
4.Guizhou Univ, Ctr R&D Fine Chem, Guiyang 550025, Peoples R China
5.Guizhou Univ, Ctr R&D Fine Chem, Guiyang 550025, Peo
关键词： Curcumin analogs;Antitumor;Apoptosis;Flow cytometry analysis
期刊名称：MEDICINAL CHEMISTRY RESEARCH （ 影响因子：1.965； 五年影响因子：1.98 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： A series of novel curcumin (CC) analogs were synthesized by reacting substituted aldehydes with intermediates 4a and 4b. The inhibitory activities of these CC analogs were investigated on human cancer cells PC3, Bcap-37, and MGC-803 in vitro by MTT assay. The results showed that most of the title compounds displayed moderate to high levels of antitumor activities. Compound 5f, the most active CC analogs, has the IC_(50) values of 1.34 ± 0.28, 3.90 ± 0.36, and 0.86 ± 0.44 uM against the three human cancer cells assayed, respectively. Furthermore, subsequent fluorescence staining and flow cytometry analysis indicated compound 5f could induce apoptosis in PC3, Bcap-37, and MGC-803 cells, and the apoptosis ratio reachs the peak (27.1 %) in MGC-803 cells at 24 h after treatment at 10 muM.
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s ; Eurotiomycetes; Lecanoromycetes; Leotiomycetes; Pezizomycetes; Phylogeny; Taxonomy -
Fungal diversity notes 603-708: taxonomic and phylogenetic notes on genera and species
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Synthesis and in vitro antitumor activity of (1E, 4E)-1-aryl-5-(2-(( quinazolin-4-yl) oxy) phenyl)-1,4-pentadien-3-one derivatives
作者：Luo, Hui;Xie, Pu;Yang, Shengjie;Hong, Da;Luo, Hui;Yang, Shengjie;Xue, Wei;Luo, Hui;Yang, Shengjie;Xue, Wei
关键词：Synthesis;Asymmetric curcumin analogs;Quinazoline derivatives of curcumin;Antitumor activity;MGC-803;Apoptosis
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Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents
作者：Luo, Hui;Cai, Yongqiang;Peng, Zhijun;Liu, Tao;Yang, Shengjie;Luo, Hui;Yang, Shengjie
关键词：Synthesis;6-Chloro-quinazolin derivatives;Antitumor;Cancer cells;Apoptosis
