PDP1 REGULATES ENERGY METABOLISM THROUGH THE IIS-TOR PATHWAY IN THE RED FLOUR BEETLE, Tribolium castaneum
文献类型： 外文期刊
作者： Li, Zhiqian 1 ; Jiang, Jianhao 1 ; Chen, Yazhou 1 ; You, Lang 1 ; Huang, Yongping 1 ; Tan, Anjiang 1 ; Li, Zhiqian 1 ; Ji 1 ;
作者机构： 1.Chinese Acad Sci, Key Lab Insect Dev & Evolutionary Biol, Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustaina
关键词： TcPDP1;T. castaneum;energy metabolism;IIS-TOR pathway;RNAi
期刊名称：ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：1.698； 五年影响因子：1.758 ）
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收录情况： SCI
摘要： The PAR-domain protein 1 (PDP1) is essential for locomotor activity of insects. However, its functions in insect growth and development have not been studied extensively, which prompted our hypothesis that PDP1 acts in energy metabolism. Here we report identification of TcPDP1 in the red flour beetle, Tribolium castaneum, and its functional analysis by RNAi. Treating larvae with dsTcPDP1 induced pupae developmental arrestment, accompanied by accelerated fat body degradation. dsTcPDP1 treatments in adults resulted in reduced female fecundity. Disruption of TcPDP1 expression affected the transcription of genes involved in insulin signaling transduction and mechanistic target of rapamycin (mTOR) pathway. These results support our hypothesis that TcPDP1 acts in energy metabolism in T. castaneum.
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