Simultaneous HPLC quantification of seven chromones in Aloe barbadensis Miller using a single reference standard
文献类型： 外文期刊
作者： Zhong, Jia-Sheng 1 ; Wan, Jin-Zhi 1 ; Liu, Yu-Peng 1 ; Ding, Wen-Jing 1 ; Wu, Xiao-Fang 2 ; Xie, Zhi-Yong 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
2.Chinese Acad Trop Agr Sci, Anal & Testing Ctr, Haikou 571101, Peoples R China
3.Hainan Prov Key Lab Qual & Safety Trop Fruits & V, Haikou 571101, Peoples R China
期刊名称：ANALYTICAL METHODS （ 影响因子：2.896； 五年影响因子：2.716 ）
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收录情况： SCI
摘要： Multi-component analysis has been considered to be one of the key techniques for quality control of traditional Chinese medicines. However, the shortage and high cost of reference standards have become the greatest obstacles in implementing this goal. An alternative method using only an easily available reference standard as the internal standard to determine multiple analogues has gained increasing attention. In the present study, a practical HPLC method was established for the simultaneous quantification of seven chromones in Aloe barbadensis Miller using a single reference standard. An easily available compound in the plant named 8-C-glucosyl-7-0-methyl-(S)-aloesol (3) was selected as the internal standard, and the other six chromones were determined by their relative response factors. The results indicated that the established method was accurate and reliable for the routine quality control of A barbadensis. 6 batches of A barbadensis samples were analyzed using this method and no significant difference was observed in the results obtained using the established method and external standard method. The newly developed method can serve as an alternative approach when reference standards are difficult to obtain. This achievement would promote the quality control of A barbadensis.
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