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Optimization of the Preparation of a Minor Bioactive Chromone in Aloe barbadensis Miller Using Response Surface Methodology and its Isolation by Reversed-Phase Flash Chromatography

文献类型： 外文期刊

作者： Zhong, Jia-Sheng 1 ; Wan, Jin-Zhi 1 ; Jiang, Xiao-Qi 1 ; Ding, Wen-Jing 1 ; Wu, Xiao-Fang 2 ; Xie, Zhi-Yong 1 ;

作者机构： 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

2.Chinese Acad Trop Agr Sci, Anal & Testing Ctr, Haikou, Peoples R China

3.Hainan Prov Key Lab Qual & Safety Trop Fruits & V, Haikou, Peoples R China

关键词： response surface methodology;reversed-phase flash chromatography;hydrolysis condition;Aloe barbadensis Miller;chromone

期刊名称：SEPARATION SCIENCE AND TECHNOLOGY （ 影响因子：2.475； 五年影响因子：2.077 ）

ISSN： 0149-6395

年卷期： 2015 年 50 卷 5 期

页码：

收录情况： SCI

摘要： A bioactive chromone, 8-C-glucosyl-7-O-methyl-(S)-aloesol (compound 1), was prepared by the acid-catalyzed hydrolysis of isoaloeresin D in Aloe barbadensis Miller. The hydrolysis conditions were successfully optimized by response surface methodology (RSM). The results indicated that RSM in the present study was adequate and effective. Then, reversed-phase flash chromatography was utilized for the isolation. In a one-step operation within 45 min, 26 mg of compound 1 was isolated from 153 mg of hydrolysis product, with a purity of 99.3%. These achievements would afford sufficient amount of high pure compound for chromatographic purpose and pharmacological activity screening.

  • 相关文献

[1]One-step Separation and Purification of Two Chromones and One Pyrone from Aloe barbadensis Miller: a Comparison Between Reversed-phase Flash Chromatography and High-speed Counter Current Chromatography. Zhong, Jia-Sheng,Wan, Jin-Zhi,Ding, Wen-Jing,Xie, Zhi-Yong,Wu, Xiao-Fang. 2014

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