Relationship between Permeability Glycoprotein (P-gp) Gene Expression and Enrofloxacin Metabolism in Nile Tilapia
文献类型： 外文期刊
作者： Hu, Kun 1 ; Cheng, Gang 2 ; Zhang, Haixin 1 ; Wang, Huicong 1 ; Ruan, Jiming 1 ; Chen, Li 1 ; Fang, Wenhong 3 ; Yang, Xia 1 ;
作者机构： 1.Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai 201306, Peoples R China
2.South Cent Coll Nationalities, Wuhan 430074, Hubei, Peoples R China
3.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China
期刊名称：JOURNAL OF AQUATIC ANIMAL HEALTH （ 影响因子：1.625； 五年影响因子：1.786 ）
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收录情况： SCI
摘要： The aim of this study was to analyze the influence of permeability glycoprotein (P-gp) gene expression on enrofloxacin (ENR) metabolism in aquatic animals. Nile Tilapia Oreochomis niloticus were fed different doses of ENR ranging from 0 to 80 mg/kg. The P-gp gene expression levels were determined by quantitative real-time PCR (qRT-PCR) at indicated time points after drug administration. Drug metabolism was determined by HPLC. The P-gp gene expression in liver and kidney was greatly enhanced 30 min after ENR administration at 40 mg/kg, peaked 3 h after drug administration, and then gradually decreased. Thirty minutes after a single oral administration of ENR (0, 20, 40, or 80 mg/kg), the P-gp gene expression increased in a dose-dependent manner. The P-gp gene expression levels in the kidney were significantly higher than those in the liver. Additionally, the metabolic rate of ENR in kidney was more rapid than that in liver. Furthermore, a close correlation was found between P-gp gene expression and ENR concentrations. These results suggest that P-gp may be involved in the ENR metabolism process in Nile Tilapia, providing a novel model for the potential utility of gene expression and drug metabolism studies in aquatic animals
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