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Discovery of Gramine Derivatives That Inhibit the Early Stage of EV71 Replication in Vitro

文献类型： 外文期刊

作者： Wei, Yanhong 1 ; Shi, Liqiao 2 ; Wang, Kaimei 2 ; Liu, Manli 2 ; Yang, Qingyu 1 ; Yang, Ziwen 1 ; Ke, Shaoyong 2 ;

作者机构： 1.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

2.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

关键词： antiviral activity;enterovirus 71;gramine derivatives

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

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收录情况： SCI

摘要： Enterovirus 71 (EV71) is a notable causative agent of hand, foot, and mouth disease in children, which is associated with an increased incidence of severe neurological disease and death, yet there is no specific treatment or vaccine for EV71 infections. In this study, the antiviral activity of gramine and 21 gramine derivatives against EV71 was investigated in cell-based assays. Eighteen derivatives displayed some degree of inhibitory effects against EV71, in that they could effectively inhibit virus-induced cytopathic effects (CPEs), but the anti-EV71 activity of the lead compound gramine was not observed. Studies on the preliminary modes of action showed that these compounds functioned by targeting the early stage of the EV71 lifecycle after viral entry, rather than inactivating the virus directly, inhibiting virus adsorption or affecting viral release from the cells. Among these derivatives, one (compound 4s) containing pyridine and benzothiazole units showed the most potency against EV71. Further studies demonstrated that derivative 4s could profoundly inhibit viral RNA replication, protein synthesis, and virus-induced apoptosis in RD cells. These results indicate that derivative 4s might be a feasible therapeutic agent against EV71 infection and that these gramine derivatives may provide promising lead scaffolds for the further design and synthesis of potential antiviral agents.

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[1]Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation. Ke, Shaoyong,Yang, Ziwen,Wang, Kaimei,Liang, Ying,Shi, Liqiao,Wei, Yanhong.

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