文献类型: 外文期刊
作者: Ke, Shaoyong 1 ; Yang, Ziwen 1 ; Zhang, Zhigang 1 ; Liang, Ying 1 ; Wang, Kaimei 1 ; Liu, Manli 1 ; Shi, Liqiao 1 ;
作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
关键词: Cytotoxic activity;Hybrids;Multisubstituted indole-acrylonitrile;Synthesis
期刊名称:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS ( 影响因子:2.823; 五年影响因子:2.677 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.
- 相关文献
作者其他论文 更多>>
-
Synthesis and Evaluation of Antifungal Activity of Novel Potent SDHI Fungicides Featuring a Conjugated Alkyne Structural Motif
作者:Bao, Longzhu;Zhou, Zifei;Yan, Xiaolong;Xu, Weilong;Li, Jun;Zhai, Qianqian;Teng, Huailong;Bao, Longzhu;Ke, Shaoyong;Chen, Yu
关键词:conjugated alkyne; succinate dehydrogenase; fungicides; enzyme activity; molecular docking
-
Natural Furan-Carboxylic Acid (HHCA) and Its Derivatives: Synthesis, Characterization, Bioevaluation, and Structure-Activity Relationships as Potential Fungicidal Agents
作者:Guo, Lirong;Wang, Hexiang;Zheng, Fuqiang;Liu, Fang;Zhang, Zhigang;Wang, Kaimei;Bao, Longzhu;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Xu, Shiyu;Cao, Xiufang;Zheng, Fuqiang;Huang, Wenbo
关键词:natural product; HHCA; structural diversity; antifungal activity; SARs
-
In vitro inhibitory activity of indole alkaloid derivatives against porcine epidemic diarrhea virus
作者:Jian, Yaoying;Dong, Siqi;Zhang, Qianyi;Pan, Jiali;Ding, Zhen;Wu, Huansheng;Chen, Zheng;Hu, Ruiming;Ke, Shaoyong
关键词:
-
From monomers to pentamers, diverse antimicrobial benzofuran polyketides from marine-derived Striaticonidium cinctum
作者:Chen, Chunmei;Cai, Jian;Chen, Yi;Yang, Bin;Liu, Yonghong;Zhou, Xuefeng;Chen, Chunmei;Cai, Jian;Chen, Yi;Yang, Bin;Liu, Yonghong;Zhou, Xuefeng;Yang, Chun;Tao, Huaming;Liu, Manli;Fang, Wei
关键词:
-
Natural pyrrolo[1,2-a]quinazolinone derivatives: Design, synthesis, characterization, and bio-evaluation as novel antiviral agents
作者:Wei, Yanhong;Zheng, Fuqiang;Chen, Wenxuan;Li, Ying;Alateng, W.;Su, Jianglong;Kong, Mengmeng;Zheng, Fuqiang;Guo, Lirong;Wang, Hexiang;Bao, Longzhu;Wu, Zhaoyuan;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang
关键词:Natural product; Pyrrolo[1; a ]quinazolinone derivatives; Antiviral agents; EV71; CVB3
-
Peptidomimetics based on natural cinnamic acid scaffold: Synthesis, bio-evaluation and structure-activity relationships
作者:Guo, Lirong;Wang, Hexiang;Liu, Fang;Bao, Longzhu;Wu, Zhaoyuan;Ye, Ting;Zhang, Yani;Wang, Yueying;Fang, Wei;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Cao, Xiufang;Duan, Liping;Duan, Liping;Duan, Liping;Duan, Liping
关键词:Natural product; Peptidomimetics; Cinnamic acid; Conjugates; Biological activity; SARs
-
Pathogenicity of Tolypocladium spp. Against Plutella xylostella: Effects on Immune Enzyme Activities and Gene Expression Profile
作者:Cai, Ni;Zhang, Zhigang;Qiao, Zhijun;Liu, Fang;Wang, Kaimei;Chang, Babar Hussain;Qiao, Zhijun;Nong, Xiangqun
关键词:Tolypocladium; Plutella xylostella; Toll pathway; enzyme activity; virulence



