The Therapeutic Effect of rhMK on Osteoarthritis in Mice, Induced by Destabilization of the Medial Meniscus
文献类型： 外文期刊
作者： Xu, Chuanying 1 ; Zhu, Shunying 1 ; Wu, Mingyuan 2 ; Zhao, Yan 3 ; Han, Wei 2 ; Yu, Yan 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
3.Shanghai Acad Agr Sci, Shanghai 201403, Peoples R China
关键词： recombinant human midkine;osteoarthritis;destabilization medial meniscus;pain
期刊名称：BIOLOGICAL & PHARMACEUTICAL BULLETIN （ 影响因子：2.233； 五年影响因子：2.309 ）
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收录情况： SCI
摘要： Osteoarthritis (OA) is a worldwide disease in aged people, causing not only physical suffering to the patients themselves, but also a great burden on their families and on society. Here we used a mouse OA model induced by destabilization of the medial meniscus (DMM), and studied the therapeutic effect of recombinant human midkine (rhMK) on this OA model. Our results indicated that the DMM surgery induced mechanical allodynia and locomotor activity obstacles, together with cartilage injury in the C57BL/6 mice. The rhMK treatment mitigated the OA related mechanical allodynia, improved locomotor activity capacity, and prevented degradation of the cartilage. Considering the safety issue of rhMK used as a biologic, we also inspected the main organs in the rhMK treated mice throughout the process and found no pathological change. These results suggest that rhMK could be used as a biologic to treat OA or OA related pain.
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