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Astakine LvAST binds to the beta subunit of F-1-ATP synthase and likely plays a role in white shrimp Litopeneaus vannamei defense against white spot syndrome virus

文献类型： 外文期刊

作者： Liang, Gao-Feng 1 ; Liang, Yan 1 ; Xue, Qinggang 2 ; Lu, Jin-Feng 1 ; Cheng, Jun-Jun 1 ; Huang, Jie 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Marine Fisheries, Minist Agr, Qingdao 266071, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Qingdao 266035, Peoples R China

3.Louisiana State Univ, Ctr Agr, Sch Anim Sci, Baton Rouge, LA 70803 USA

关键词： Astakine;Invertebrate cytokine;White spot syndrome virus;Shrimp antiviral immunity;F-1-ATP synthase beta subunit

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

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收录情况： SCI

摘要： Cytokines play a critical role in innate and adaptive immunity. Astakines represent a group of invertebrate cytokines that are related to vertebrate prokineticin and function in promoting hematopoiesis in crustaceans. We have identified an astakine from the white shrimp Litopeneaus vannamei and named it LvAST in a previous research. In the present research, we investigated the interactions among LvAST, the envelope protein VP37 of white spot syndrome virus (i.e., WSSV), and the beta subunit of F-1-ATP synthase (ATPsyn-beta) of the white shrimp (i.e., BP53) using binding assays and co-precipitations. We also examined the effects of LvAST on shrimp susceptibility to WSSV. We found that LvAST and VP37 competitively bound to BP53, but did not bind to each other. Shrimps that had been injected with recombinant LvAST exhibited significantly lower mortality and longer survival time in experimental infections by WSSV. In contrast, shrimps whose LvAST gene expression had been inhibited by RNA interference showed significantly higher WSSV infection intensity and shorter survival time following viral challenges. These results suggested that LvAST and WSSV both likely use ATPsyn-beta as a receptor and LvAST plays a role in shrimp defense against WSSV infection. This represented the first research showing the involvement of astakines in host antiviral immunity. (C) 2014 Elsevier Ltd. All rights reserved.

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