您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Anti-Inflammatory Effect of the Blueberry Anthocyanins Malvidin-3-Glucoside and Malvidin-3-Galactoside in Endothelial Cells

文献类型： 外文期刊

作者： Huang, Wu-Yang 1 ; Liu, Ya-Mei 2 ; Wang, Jian 1 ; Wang, Xing-Na 1 ; Li, Chun-Yang 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Dept Funct Food & Bioact Cpds, Nanjing 210014, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Tech Res Ctr Vet Biol Prod, Nanjing 210014, Peoples R China

3.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

关键词： anthocyanins;anti-inflammatory effect;blueberry;malvidin-3-galactoside;malvidin-3-glucoside

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Blueberry fruits have a wide range of health benefits because of their abundant anthocyanins, which are natural antioxidants. The purpose of this study was to investigate the inhibitory effect of blueberry's two main anthocyanins (malvidin-3-glucoside and malvidin-3-galactoside) on inflammatory response in endothelial cells. These two malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-alpha) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mRNA levels in a concentration-dependent manner. Mv-3-glc at the concentration of 1 mu M could inhibit 35.9% increased MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein in supernatant, as well as 9.88% MCP-1 and 48.6% ICAM-1 mRNA expression (p < 0.05). In addition, they could decrease I kappa B alpha degradation (Mv-3-glc, Mv-3-gal, and their mixture at the concentration of 50 mu M had the inhibition rate of 84.8%, 75.3%, and 43.2%, respectively, p < 0.01) and block the nuclear translocation of p65, which suggested their anti-inflammation mechanism was mediated by the nuclear factor-kappa B (NF-kappa B) pathway. In general malvidin-3-glucoside had better anti-inflammatory effect than malvidin-3-galactoside. These results indicated that blueberry is good resource of anti-inflammatory anthocyanins, which can be promising molecules for the development of nutraceuticals to prevent chronic inflammation in many diseases.

  • 相关文献

[1]Composition of Polyphenols and Antioxidant Activity of Rabbiteye Blueberry (Vaccinium ashei) in Nanjing. Li, Chunyang,Feng, Jin,Huang, Wu-Yang,An, Xiao-Ting,Feng, Jin.

[2]Malvidin and its Glycosides from Vaccinium ashei Improve Endothelial Function by Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory Effects. Huang, Wu-Yang,Wang, Xing-Na,Wang, Jing,Sui, Zhong-Quan. 2018

[3]Anatomical and biochemical analysis reveal the role of anthocyanins in flower coloration of herbaceous peony. Zhao, Da-Qiu,Wei, Meng-Ran,Liu, Ding,Tao, Jun,Zhao, Da-Qiu,Wei, Meng-Ran,Liu, Ding,Tao, Jun.

[4]Gene regulation of anthocyanin biosynthesis in two blood-flesh peach (Prunus persica (L.) Batsch) cultivars during fruit development. Jiao, Yun,Ma, Rui-juan,Shen, Zhi-jun,Yan, Juan,Yu, Ming-liang. 2014

[5]Study on Antibacterial Activity of Anthocyanins from Blueberry Wine Pomace. Liu, Chen,Liu, Anjun,Ma, Yanhong,Huang, Kaihong,Li, Yahui,Zhang, Hongzhi. 2015

[6]Profiling polyphenols of two diploid strawberry (Fragaria vesca) inbred lines using UHPLC-HRMSn. Sun, Jianghao,Chen, Pei,Liu, Xianjin,Yang, Tianbao,Slovin, Janet. 2014

[7]Characterization and genetic mapping of a new blood-flesh trait controlled by the single dominant locus DBF in peach. Shen, Zhijun,Yu, Mingliang,Ma, Ruijuan,Confolent, Carole,Lambert, Patrick,Poessel, Jean-Luc,Quilot-Turion, Benedicte,Pascal, Thierry. 2013

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台