Mulberry leaf phenolics ameliorate hyperglycemia-induced oxidative stress and stabilize mitochondrial membrane potential in HepG2 cells
文献类型: 外文期刊
作者: Zou, Yu-Xiao 1 ; Shen, Wei-Zhi 1 ; Liao, Sen-Tai 1 ; Liu, Fan 1 ; Zheng, Shan-Qing 1 ; Blumberg, Jeffrey B. 2 ; Chen, 1 ;
作者机构: 1.Guangdong Acad Agr Sci, Sericulture & Agri Food Res Inst, Guangzhou, Guangdong, Peoples R China
2.Tufts Univ, Antioxidants Res Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA
关键词: HepG2;hyperglycemia;mitochondria;mulberry leaves;oxidative stress;phenolics
期刊名称:INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION ( 影响因子:3.833; 五年影响因子:3.859 )
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收录情况: SCI
摘要: To investigate the effect of phenolics in mulberry leaves (mulberry leaf phenolics; MLP) on hyperglycemia-induced oxidative stress and mitochondrial membrane potential (Delta Psi m) in HepG2 cells; we treated HepG2 with glucose [5.5 (N-Glc) or 50 mmol/L (Hi-Glc)] with or without MLP at 10 or 100 mmol/L gallic acid equivalents and assessed level of reactive oxidant species (ROS), Delta Psi m, malondialdehyde (MDA) and nuclear factor-kappaB (NF-kappa B) activation. Hi-Glc-induced oxidative damage was demonstrated by a series of increase in superoxides (560%, 0.5 h), MDA (400%, 24 h), NF-kappa B activation (474%, 4 h) and a wild fluctuation of Delta Psi m relative to the control cells (p <= 0.05). MLP treatments ameliorate Hi-Glc-induced negative effects by a 40% reduction in ROS production, 34-44% reduction in MDA production, over 35% inhibition of NF-kappa B activation, as well as exert protective effect on HepG2 cells from change in Delta Psi m. Our data show that MLP in vitro can protect hepatoctyes from hyperglycemia-induced oxidative damages.
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