The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China
文献类型： 外文期刊
作者： Chen, Baowei 1 ; Liang, Ximei 3 ; Nie, Xiangping 5 ; Huang, Xiaoping 3 ; Zou, Shichun 2 ; Li, Xiangdong 1 ;
作者机构： 1.Hong Kong Polytech Univ, Dept Civil & Environm Engn, Kowloon, Hong Kong, Peoples R China
2.Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510275, Guangdong, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
4.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou 510380, Guangdong, Peoples R China
5.Jinan Univ, Inst Hydrobiol, Dept Ecol, Guangzhou 510632, Guangdong, Peoples R China
关键词： Antibiotic resistance genes (ARC);Sulfonamide resistance genes (sul1 and sul2);Class 1 intergron;Pearl River Estuary (PRE);South China
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Antibiotic resistance genes (ARGs), as a newly emerging contaminant, are unique because they are disseminated through horizontal gene transfer in the environment. In the present study, a class 1 integron gene (Int1) and various ARGs (sul1, sul2, sul3, qnrS, and ermB) were measured in water and sediment samples from the Pearl River (PR) to the Pearl River Estuary (PRE), where there is a distinct gradient in anthropogenic impact. The int1, sul1, and sul2 genes were detected in all samples, and their concentrations exhibited a clear trend of decline consistent with anthropogenic impact. Both the int1 and sul genes had dynamically migrated between water and sediments. The relative abundance of the Intl gene normalized to the 16S rRNA gene correlated significantly with the total concentrations of antibiotics in water and sediments. Good correlations were also observed between the abundance of Intl and each type of sul gene in the samples. However, the sul1 gene showed a much stronger relationship with intl in different seasons, probably due to the presence of sul1 in the conserved region of class 1 integron. Our results strongly support that integrons play an important role in the dissemination of ARGs in human-impacted aquatic environments. (C) 2014 Elsevier B.V. All rights reserved.
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