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Transcriptome analysis revealed positive selection of immune-related genes in tilapia

文献类型： 外文期刊

作者： Xiao, Jun 1 ; Zhong, Huan 1 ; Liu, Zhen 2 ; Yu, Fan 3 ; Luo, Yongju 1 ; Gan, Xi 1 ; Zhou, Yi 1 ;

作者机构： 1.Guangxi Acad Fishery Sci, Guangxi Key Lab Aquat Genet Breeding & Healthy Aq, Nanning 530021, Guangxi, Peoples R China

2.Changsha Univ, Dept Biotechnol & Environm Sci, Changsha 410003, Hunan, Peoples R China

3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Genet Breeding Aquat Anim, Wuxi 214081, Jiangsu, Peoples R China

关键词： Blue tilapia;High-throughput sequencing;Positive selection;Immune genes;Divergence time

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

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收录情况： SCI

摘要： High-throughput sequencing of transcriptome promises a new approach for detecting evolutionary divergence among species. Up to now, the information about evolution of immune genes in cultured fish, especially in tilapias which would aid to understand the molecular basis of immune phenotypic differentiation is still lack. Thus, in the present study, we used high-throughput sequencing to obtain large amount of gene sequences in blue tilapia and characterized the diversity of orthologs among Nile tilapia, blue tilapia and zebrafish. A total of 52,424,506 raw reads, representing 31,404 unigenes were obtained from blue tilapia cDNA library of mixed tissues, including brain, pituitary, gill, heart, liver, spleen, kidney, intestine, muscle, testis and ovary. Based on Ks value, we calculated that the divergence time between Nile tilapia and blue tilapia is 2.93 million years ago. And the tilapias are both apart from zebrafish in 197 million years ago. Furthermore, the positive selected genes were identified by calculating of Ka/Ks ratio. Several immune-related genes were identified as positively selected genes, such as Notch2 and nfatc3b. Considering that these genes play crucial role in immune regulating function, the immune system genes met a great variation under environment selection in tilapias which suggests fast evolution in immune system of cultured tilapias. (C) 2015 Elsevier Ltd. All rights reserved.

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