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The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry

文献类型： 外文期刊

作者： Ni, Bo 1 ; Wen, Li-Bin 2 ; Wang, Rui 1 ; Hao, Hong-Ping 1 ; Huan, Chang-Chao 1 ; Wang, Xin 1 ; Huang, Li 1 ; Miao, Jin-Fe 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Natl Ctr Engn Res Vet Bioprod, Key Lab Vet Biol Engn & Technol, Minist Agr, Inst Vet Med,Jiangsu Acad Agr Sci, Nanjing 210014, Jiangsu, Peoples R China

3.Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

关键词： Porcine reproductive and respiratory syndrome virus;Infection;FAK;Rac1

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

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收录情况： SCI

摘要： CD163 and sialoadhesin had been reported as the two receptors for porcine reproductive and respiratory syndrome virus (PRRSV) infection. The signaling pathway activated by PRRSV entry was seldom reported. In our studies, we demonstrated that PRRSV entry triggers FAK, PI3K, AKT and Rac1 activation. The signaling pathway FAK-PI3K-AKT-Rac1 is essential for PRRSV entry. Blocking FAR by PF573228 attenuates the activation of PI3K, ART, Rac1 and the cytoskeleton remodeling induced by virus entry. Inhibitors to FAR, PI3K, AKT and Rac1 can significantly inhibit the virus entry. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells. (C) 2015 Elsevier Inc. All rights reserved.

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