The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
文献类型： 外文期刊
作者： Yu, Yong 1 ; Wang, Cui 1 ; Clare, Simon 1 ; Wang, Juexuan 1 ; Lee, Song-Choon 1 ; Brandt, Cordelia 1 ; Burke, Shannon; 1 ;
作者机构： 1.Wellcome Trust Sanger Inst, Cambridge CB10 1HH, England
2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China
3.Methodist Hosp, Res Inst, Houston, TX 77030 USA
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China
期刊名称：JOURNAL OF EXPERIMENTAL MEDICINE （ 影响因子：14.307； 五年影响因子：14.851 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in similar to 28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
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