文献类型： 外文期刊

作者： Kong, Weili ¹ ; Wang, Feibing ⁴ ; Dong, Bin ¹ ; Ou, Changbo ⁵ ; Meng, Demei ¹ ; Liu, Jinhua ² ; Fan, Zhen-Chuan ¹ ;

作者机构： 1.Tianjin Univ Sci & Technol, Minist Educ China, Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China

2.China Agr Univ, State Key Lab Agrobiotechnol, Coll Vet Med, Key Lab Anim Epidemiol & Zoonosis,Minist Agr, Beijing 100193, Peoples R China

3.Obesita & Algaegen LLC, College Stn, TX 77845 USA

4.Shanghai Acad Agr Sci, Biotech Res Inst, Shanghai Key Lab Agr Genet Breeding, Shanghai 201106, Peoples R China

5.Henan Inst Sci & Technol, Coll Anim Sci, Xinxiang 453000, Peoples R China

关键词： Pdm/09 H1N1;Swine influenza;Canine influenza;Human influenza;Reassortant

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

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收录情况： SCI

摘要： Influenza A virus (IAV) is characterized by eight single-stranded, negative sense RNA segments, which allows for gene reassortment among different IAV subtypes when they co-infect a single host cell simultaneously. Genetic reassortment is an important way to favor the evolution of influenza virus. Novel reassortant virus may pose a pandemic among humans. In history, three human pandemic influenza viruses were caused by genetic reassortment between avian, human and swine influenza viruses. Since 2009, pandemic (H1N1) 2009 (pdm/09 H1N1) influenza virus composed of two swine influenza virus genes highlighted the genetic reassortment again. Due to wide host species and high transmission of the pdm/09 H1N1 influenza virus, many different avian, human or swine influenza virus subtypes may reassert with it to generate novel reassortant viruses, which may result in a next pandemic among humans. So, it is necessary to understand the potential threat of current reassortant viruses between the pdm/09 H1N1 and other influenza viruses to public health. This study summarized the status of the reassortant viruses between the pdm/09 H1N1 and other influenza viruses of different species origins in natural and experimental conditions. The aim of this summarization is to facilitate us to further understand the potential threats of novel reassortant influenza viruses to public health and to make effective prevention and control strategies for these pathogens. (C) 2015 Elsevier Ltd. All rights reserved.