The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
文献类型： 外文期刊
作者： Zhou, Guang Fang 1 ; Liu, Qing Tao 2 ; Zhou, Bin 1 ; Qiu, Ya Feng 3 ; Liu, Xiao Dong 1 ; Ma, Zhi Yong 3 ; Feng, Xiu Li 1 ;
作者机构： 1.Nanjing Agr Univ, Chinas Dept Agr, Coll Vet Med, Div Key Lab Anim Dis Diag & Immunol, Nanjing 210095, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China
3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
关键词： bursal septpeptide II;humoral immune system;pathway analysis;tumor suppressor p53
期刊名称：JOURNAL OF VETERINARY SCIENCE （ 影响因子：1.672； 五年影响因子：1.904 ）
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收录情况： SCI
摘要： The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway. analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.
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