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Optimization of selenylation modification for garlic polysaccharide based on immune-enhancing activity

文献类型： 外文期刊

作者： Gao, Zhenzhen 1 ; Chen, Jin; Qiu, Shulei 1 ; Li, Youying 1 ; Wang, Deyun 1 ; Liu, Cui 1 ; Li, Xiuping 1 ; Hou, Ranran; 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R C

关键词： Garlic polysaccharide;Selenylation modification;Lymphocyte proliferation;Cytokines Immune response

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

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收录情况： SCI

摘要： Garlic polysaccharide (GPS) was modified in selenylation respectively by nitric acid-sodium selenite (NA-SS), glacial acetic acid-selenous acid (GA-SA), glacial acetic acid-sodium selenite (GA-SS) and selenium oxychloride (SOC) methods each under nine modification conditions of L-9 (3(4)) orthogonal design and each to obtain nine selenizing GPSs (sGPSs). Their structures were identified, yields and selenium contents were determined, selenium yields were calculated, and the immune-enhancing activities of four sGPSs with higher selenium yields were compared taking unmodified GPS as control. The results showed that among four methods the selenylation efficiency of NA-SS method were the highest, the activity of sGPS(5) was the strongest and significantly stronger than that of unmodified GPS. This indicates that selenylation modification can significantly enhance the immune-enhancing activity of GPS, NA-SS method is the best method and the optimal conditions are 0.8:1 weight ratio of sodium selenite to GPS, reaction temperature of 70 degrees C and reaction time of 10 h. (C) 2015 Elsevier Ltd. All rights reserved.

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