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Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp CJK17 on marine fish ciliate Cryptocaryon irritans

文献类型： 外文期刊

作者： Yin, Fei 1 ; Sun, Peng 1 ; Tang, Baojun 1 ; Gong, Hui 2 ; Ke, Qiaozhen 3 ; Li, Anxing 4 ;

作者机构： 1.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Minist Agr, Key Lab East China Sea & Ocean Fishery Resources, Shanghai 200090, Peoples R China

2.Fujian Acad Agr Sci, Inst Biotechnol, Fuzhou 350003, Fujian Province, Peoples R China

3.Ningde Fufa Fisheries Co Ltd, Ningde 352000, Fujian Province, Peoples R China

4.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Key Lab Aquat Prod Safety,Minist Educ, Guangzhou 510275, Guangdong, Peoples R China

关键词： Cryptocaryon irritans;Larimichthys crocea;Leptomycin B;Streptomycete;Fermentation products

期刊名称：VETERINARY PARASITOLOGY （ 影响因子：2.738； 五年影响因子：2.951 ）

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收录情况： SCI

摘要： The present study was conducted aiming to evaluate the in vitro and in vivo anti-parasitic efficacy of an isolated compound against the ciliate Cryptocaryon irritans. The compound was previously isolated from fermentation products of Streptomyces sp. CJK17 and designated as SFrD. Toxicity of the compound SFrD against the fish hosts (Larimichthys crocea) was also tested and its chemical structure was elucidated. The obtained results showed that the compound has potent anti-parasitic efficacy with the 10min-, 1 h-, 2 h-, 3 h- and 4 h-LC50 (95% Confidence Intervals) of 6.8 (6.5-7.1), 3.9 (2.8-5.0), 3.3 (2.6-4.0), 2.7 (23-3.1) and 2.5 (2.2-2.8) mg L-1 against theronts of C irritans and the 6 h-LC50 (95% CI) of 3.0 (2.8-3.2) mg L-1 against the tomonts, respectively. Exposure of the compound SFrD remarkably reduced the mortality of fish infected with C Irritans, from 100% in the control group to 61.7% and 38.3% in groups of 3.1 mg L-1 and 6.3 mg L-1, respectively. In the test of exposing fish to 40 mg L-1 compound SFrD for 24 h, no visible effects were observed affecting the normal behavior or any macroscopic changes. By spectrum analysis (EI-MS, H-1 NMR and C-13 NMR), the compound SFrD was identified as Leptomycin B. This study firstly demonstrated that Leptomycin B has potent anti-parasitic efficacy against ciliates in cultured marine fish. (C) 2015 Elsevier B.V. All rights reserved.

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[1]Transcriptome and analysis on the complement and coagulation cascades pathway of large yellow croaker (Larimichthys crocea) to ciliate ectoparasite Cryptocaryon irritans infection. Yin, Fei,Gao, Quanxin,Tang, Baojun,Sun, Peng,Han, Kunhuang,Huang, Weiqing,Han, Kunhuang,Huang, Weiqing.

[2]Characterization of E3 ubiquitin ligase neuregulin receptor degradation protein-1 (Nrdp1) in the large yellow croaker (Larimichthys crocea) and its immune responses to Cryptocaryon irritans. Zhang, Dong Ling,Han, Fang,Xiao, Shi Jun,Chen, Jian,Wang, Zhi Yong,Yu, Da Hui,Li, Ming Yun.

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[8]Growth, feed intake and immune responses of orange-spotted grouper (Epinephelus coioides) exposed to low infectious doses of ectoparasite (Cryptocaryon irritans). Yin, Fei,Sun, Peng,Shi, Zhao-Hong,Gao, Quan-Xin,Peng, Shi-Ming,Dan, Xue-Ming,Li, An-Xing. 2014

[9]Ultrastructural features of the tomont of Cryptocaryon irritans (Ciliophora: Prostomatea), a parasitic ciliate of marine fishes. Ma, Rui,Fan, Xinpeng,Ni, Bing,Gu, Fukang,Yin, Fei. 2017

[10]Transcriptome analysis of dormant tomonts of the marine fish ectoparasitic ciliate Cryptocaryon irritans under low temperature. Yin, Fei,Sun, Peng,Gao, Quanxin,Wang, Jiteng. 2016

[11]Effects of Cryptocaryon irritans infection on the survival, feeding, respiratory rate and ionic regulation of the marbled rockfish Sebastiscus marmoratus. Yin, Fei,Sun, Peng,Gao, Quanxin,Shi, Zhaohong,Peng, Shiming,Gong, Qiyang,Li, Yanwei,Li, Anxing,Dan, Xueming. 2014

[12]Immunological, ionic and biochemical responses in blood serum of the marine fish Trachinotus ovatus to poly-infection by Cryptocaryon irritans. Yin, Fei,Sun, Peng,Tang, Baojun,Dan, Xueming,Li, Anxing.

[13]Molecular characterization and functional analysis of TRAF6 in orange-spotted grouper (Epinephelus coioides). Li, Yan-Wei,Li, Xia,Xiao, Xi-Xi,Li, An-Xing,Zhao, Fei,Luo, Xiao-Chun,Dan, Xue-Ming.

[14]Stress, antioxidant defence and mucosal immune responses of the large yellow croaker Pseudosciaena crocea challenged with Cryptocaryon irritans. Yin, Fei,Gong, Hui,Ke, Qiaozhen,Li, Anxing.

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