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Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp HCa1

文献类型： 外文期刊

作者： Guo, Zhi-Kai 1 ; Yan, Wei 2 ; Tan, Ren-Xiang 2 ; Ge, Hui-Ming 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

2.Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

关键词： Amycolatopsis;Pseudonocardiaceae;grasshopper;tetrasaccharide

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

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收录情况： SCI

摘要： A new tetrasaccharide derivative, actinotetraose L (1), was isolated from the methanol extract of the mycelia of the grasshopper-associated rare actinobacterium Amycolatopsis sp. HCa1. The structure of the new compound was elucidated by a combination of 1D, 2D NMR (HMQC, HMBC, COSY, and NOESY), and HR-ESI-MS analyses as O-{3,4-di-O-[(E)-2-ethyl-2-butenoyl]- beta-D-glucopyranosyl-(1 -> 2)}-O-{3,4-di-O-[(E)-2-methyl-2-butenoyl]-beta-D-glucopyranosyl-(1 -> 2)}-6,6-di-O-[(E)-2-methyl-2-butenoyl]-alpha-D-glucopyranosyl-(1 -> 1)-alpha-D-glucopyranoside. The immunosuppressive activity and cytotoxicity of the compound were evaluated by T-cell viability and MTT assays. Nonetheless, no significant activity was observed.

  • 相关文献

[1]Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp HCa1. Guo, Zhi Kai,Zhang, Gao Fei,Jiao, Rui Hua,Shen, Yan,Xu, Qiang,Tan, Ren Xiang,Ge, Hui Ming,Guo, Zhi Kai,Guo, Zhi Kai. 2012

[2]Angucyclines from an insect-derived actinobacterium Amycolatopsis sp HCa1 and their cytotoxic activity. Jiao, Rui Hua,Wang, Ting,Tan, Ren Xiang,Ge, Hui Ming,Guo, Zhi Kai,Liu, Shou Bai. 2012

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