文献类型： 外文期刊
作者： Guo, Zhi-Kai 1 ; Chen, Bi-Ting 1 ; Chen, Dan-Dan 3 ; Deng, Xiao-Ling 3 ; Xu, Jing 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China
2.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China
3.Hainan Univ, Sch Chem & Chem Engn, Haikou 570208, Peoples R China
关键词：
Mangrove; endophytic fungus;
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.3； 五年影响因子：1.6 ）
ISSN： 1028-6020
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Chemical investigation of the mangrove-derived fungus Phomopsis sp. DHS-11 led to the isolation of three new pyrone derivatives (1-3), and a new natural product (4). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of 13C NMR data and analysis of the coupling constants and NOESY correlations. Compounds 2 and 3 exhibited significant cytotoxicity against HepG2 with IC50 values of 4.66 +/- 0.35 mu M and 6.07 +/- 0.48 mu M, respectively. Compound 3 showed moderate cytotoxicity against Hela cells with IC50 value of 20.2 +/- 4.93 mu M.
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