您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Degradation of chondroitin sulfate by the gut microbiota of Chinese individuals

文献类型： 外文期刊

作者： Shang, Qingsen 1 ; Yin, Yeshi 3 ; Zhu, Liying 3 ; Li, Guoyun 1 ; Yu, Guangli 1 ; Wang, Xin 3 ;

作者机构： 1.Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Peoples R China

2.Ocean Univ China, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Chondroitin sulfate;Degradation;Clostridium hathewayi

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Oral preparations of chondroitin sulfate (CS) have long been used as anti-osteoarthritis (anti-OA) drugs. However, little is known about the degradation of CS by human gut microbiota. In the present study, degradation profiles of CSA (the main constituent of CS drugs) by the human gut microbiota from six healthy subjects were investigated. Each individual's microbiota had differing degradation activities, but Delta UA-GalNAc4S was the end product in all cases. To elucidate the mechanisms underlying this phenomenon, different CSA-degrading bacteria were isolated from each individual's microbiota and tested for CSA degradation. In addition to Bacteroides thetaiotaomicron J1, Bacteroides thetaiotaomicron 82 and Bacteroides ovatus E3, a new CSA-degrading bacterium, Clostridium hathewayi R4, was isolated and characterized. Interestingly, at least two different CSA-degrading species were identified from each individual's gut microbiota. Predictably, these functional bacteria also had differing degradation rates, but still generated the same end product, Delta UA-GalNAc4S. In addition, the human fecal isolates produced different degradation profiles for CSC, CSD, and CSE, suggesting that CS could be readily metabolized to varying extents by diverse microbial consortiums, which may help to explain the poor bioavailability and unequal efficacy of CS among individuals in OA treatment. (C) 2016 Elsevier B.V. All rights reserved.

  • 相关文献

[1]Litterbag decomposition of residues from Bacillus thuringiensis (Bt) rice hybrids and the parental lines under multiple field conditions. Xiao, Manqiu,Fang, Changming,Dong, Shanshan,Luo, Fuhua,Song, Zhiping,Tang, Xu,Chen, Yi,Yang, Shengmao,Wang, Feng,Su, Jun. 2014

[2]Adsorption Properties and Degradation Dynamics of Endocrine-Disrupting Chemical Levonorgestrel in Soils. Xia, Jinming,Hu, Qiongbo,Tang, Tao,Shi, Tianyu,Li, Deguang,Cao, Yongsong,Tang, Tao.

[3]Residues of chlorantraniliprole in rice field ecosystem. Chai, Wei-Gang,Wu, Yin-Liang,Zhang, Jin-Ming.

[4]Enantioselective degradation of tebuconazole in cabbage, cucumber, and soils. Wang, Xinquan,Zhang, Hu,Wu, Changxing,Wang, Xiangyun,Xu, Hao,Wang, Xiaofu,Li, Zhen,Wang, Xuesong.

[5]Residue Analysis and Degradation Studies of Fenbuconazole and Myclobutanil in Strawberry by Chiral High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Zhang, Hu,Wang, Xinquan,Qian, Mingrong,Wang, Xiangyun,Xu, Hao,Xu, Mingfei,Wang, Qiang.

[6]Simultaneous determination of florfenicol with its metabolite based on modified quick, easy, cheap, effective, rugged, and safe sample pretreatment and evaluation of their degradation behavior in agricultural soils. Xu, Mingfei,Qian, Mingrong,Zhang, Hu,Wang, Jianmei,Wu, Huizhen,Ma, Junwei.

[7]Fate of Fenhexamid in Water-Sediment Systems: Degradation Under Aerobic/Anaerobic Conditions and Bioaccumulation by Zebrafish (Danio rerio). Xu, Zhenlan,Hu, Xiuqing,Wu, Min,Tang, Tao,Zhang, Changpeng,He, Hongmei,Yu, Jianzhong,Lou, Fangyuan,Wu, Yuanyuan,Wang, Yanhua,Chen, Liezhong,Zhao, Hua,Wang, Qiang,Cai, Leiming.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台