Syndecan-4, a PRRSV attachment factor, mediates PRRSV entry through its interaction with EGFR
文献类型： 外文期刊
作者： Wang, Rui 1 ; Wang, Xin 1 ; Ni, Bo 1 ; Huan, Chang-chao 1 ; Wu, Jia-qiang 3 ; Wen, Li-bin 4 ; Liao, Ying 2 ; Tong, Guang- 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Beijing, Peoples R China
3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Beijing, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
关键词： Porcine reproductive and respiratory;syndrome virus;Attachment;Entry;Syndecan-4;EGFR
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： The causative agent of porcine reproductive and respiratory syndrome is the PRRS virus (PRRSV), an enveloped, single-stranded and positive-sense RNA virus. The host factors and mechanisms that are involved in PRRSV entry are still largely unknown. In our present studies, we found that syndecan-4, one of the heparan sulfate proteoglycans, plays a critical role in PRRSV entry, especially in PRRSV attachment. Moreover, EGFR interacts with syndecan-4 in MACR-145 cells and disruption of their interaction impaired PRRSV entry. Furthermore, EGFR inhibitor AG1478 or syndecan-4 derived peptide SSTN87-131 inhibited syndecan-4 endocytosis induced by PRRSV entry. Altogether, syndecan-4, a PRRSV attachment factor, mediated PRRSV entry by interacting with EGFR. (C) 2016 Elsevier Inc. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Knockdown of tyrosine hydroxylase gene affects larval survival, pupation and adult eclosion in Plagiodera versicolora
作者：Liu, Xiaolong;Wang, Xin;Zhang, Qi;Lu, Min;Ze, Longji;Zhang, Hainan
关键词：cuticle tanning; mortality;
Plagiodera versicolora ; RNA interference; tyrosine hydroxylase -
Biological delignification and anaerobic fermentation of wheat straw: A promising approach for sustainable utilization of crop straw bioresources
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Crop residues; Wheat straw; Lignin degradation; Anaerobic fermentation; Enzymatic hydrolysis; In vitro digestibility
-
Evaluation of growth stage and storage time on fermentation characteristics, microbial community structure, co-occurrence networks, and their functional shifts and pathogenic risk of fermented Italian ryegrass
作者：Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi;Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi
关键词：Growth stage; Fermentation product; Microbial community; Lolium multiflorum; Microbial risk
-
Effect of biological lignin depolymerization on rice straw enzymatic hydrolysis, anerobic fermentation characteristics and in vitro ruminal digestibility
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Rice straw; Lignin depolymerization; Ensiling; Enzymatic hydrolysis; In vitro digestibility
-
Comparative Analysis of Phenolic Acid Metabolites and Differential Genes Between Browning-Resistant and Browning-Sensitive luffa During the Commercial Fruit Stage
作者：Feng, Yingna;Gao, Shuai;Wang, Rui;Liu, Yeqiong;Yan, Zhiming;Fang, Yichen;Zhu, Simin;Wang, Yuanhua;Feng, Yingna;Wang, Rui;Yan, Zhiming;Wang, Yuanhua;Yong, Mingli;Feng, Cui;Ni, Weichen;Liu, Liwang
关键词：
luffa cylindrica ; transcriptome; metabolome; browning; gene expression -
A Study of Growth and Yield of Four Peanut Varieties with Rhizobia Inoculation under Field Conditions
作者：Ding, Bin;Feng, Mengshi;Wang, Rui;Chang, Lei;Jiang, Ying;Xie, Jixian;Tian, Da
关键词：Arachis hypogaea L.; rhizobia agent; root nodules; yield
-
A Scalable and Robust Chloroplast Genotyping Solution: Development and Application of SNP and InDel Markers in the Maize Chloroplast Genome
作者：Wang, Rui;Yang, Yang;Tian, Hongli;Yi, Hongmei;Xu, Liwen;Ge, Jianrong;Zhao, Yikun;Wang, Lu;Wang, Fengge;Lv, Yuanda;Zhou, Shiliang
关键词：chloroplast; SNP; InDel; high throughput; genotyping; maize
