Syndecan-4, a PRRSV attachment factor, mediates PRRSV entry through its interaction with EGFR
文献类型： 外文期刊
作者： Wang, Rui 1 ; Wang, Xin 1 ; Ni, Bo 1 ; Huan, Chang-chao 1 ; Wu, Jia-qiang 3 ; Wen, Li-bin 4 ; Liao, Ying 2 ; Tong, Guang- 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Beijing, Peoples R China
3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Beijing, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
关键词： Porcine reproductive and respiratory;syndrome virus;Attachment;Entry;Syndecan-4;EGFR
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）
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年卷期：
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收录情况： SCI
摘要： The causative agent of porcine reproductive and respiratory syndrome is the PRRS virus (PRRSV), an enveloped, single-stranded and positive-sense RNA virus. The host factors and mechanisms that are involved in PRRSV entry are still largely unknown. In our present studies, we found that syndecan-4, one of the heparan sulfate proteoglycans, plays a critical role in PRRSV entry, especially in PRRSV attachment. Moreover, EGFR interacts with syndecan-4 in MACR-145 cells and disruption of their interaction impaired PRRSV entry. Furthermore, EGFR inhibitor AG1478 or syndecan-4 derived peptide SSTN87-131 inhibited syndecan-4 endocytosis induced by PRRSV entry. Altogether, syndecan-4, a PRRSV attachment factor, mediated PRRSV entry by interacting with EGFR. (C) 2016 Elsevier Inc. All rights reserved.
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