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Role of thymosin beta 4 in hair growth

文献类型： 外文期刊

作者： Gao, Xiao-yu 1 ; Hou, Fang 1 ; Zhang, Zhi-peng 1 ; Nuo, Ming-tu 1 ; Liang, Hao 1 ; Cang, Ming 1 ; Wang, Zhi-gang 2 ; Wang 1 ;

作者机构： 1.Inner Mongolia Univ, Natl Res Ctr Anim Transgen Biotechnol, Hohhot 010070, Peoples R China

2.Inner Mongolia Univ, Sch Life Sci, Hohhot 010020, Peoples R China

3.Wenzhou Med Univ, Inst Biomed Informat, Sch Lab Med & Life Sci, Wenzhou 325000, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Anim

关键词： Thymosin beta4;Hair re-growth;Hair follicle;Wnt

期刊名称：MOLECULAR GENETICS AND GENOMICS （ 影响因子：3.291； 五年影响因子：3.257 ）

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年卷期：

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收录情况： SCI

摘要： Although thymosin beta 4 (T beta 4) is known to play a role in hair growth, its mechanism of action is unclear. We examined the levels of key genes in a T beta 4 epidermal-specific over-expressing mouse model and T beta 4 global knockout mouse model to explore how T beta 4 affects hair growth. By depilation and histological examination of the skin, we confirmed the effect of T beta 4 on hair growth, the number of hair shafts and hair follicle (HF) structure. The mRNA and protein expression of several genes involved in hair growth were detected by real-time PCR and western blotting, respectively. Changes in the expression of beta-catenin and Lef-1, the two key molecules in the Wnt signaling pathway, were similar to the changes observed in T beta 4 expression. We also found that compared to the control mice, the mRNA and protein expression of MMP-2 and VEGF were increased in the T beta 4 over-expressing mice, while the level of E-cadherin (E-cad) remained the same. Further, in the T beta 4 global knockout mice, the mRNA and protein levels of MMP-2 and VEGF decreased dramatically and the level of E-cad was stable. Based on the above results, we believe that T beta 4 may regulate the levels of VEGF and MMP-2 via the Wnt/beta-catenin/Lef-1 signaling pathway to influence the growth of blood vessels around HFs and to activate cell migration. T beta 4 may have potential for the treatment of hair growth problems in adults, and its effects should be further confirmed in future studies.

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