文献类型： 外文期刊
作者： Gao, Xiao-yu 1 ; Hou, Fang 1 ; Zhang, Zhi-peng 1 ; Nuo, Ming-tu 1 ; Liang, Hao 1 ; Cang, Ming 1 ; Wang, Zhi-gang 2 ; Wang 1 ;
作者机构： 1.Inner Mongolia Univ, Natl Res Ctr Anim Transgen Biotechnol, Hohhot 010070, Peoples R China
2.Inner Mongolia Univ, Sch Life Sci, Hohhot 010020, Peoples R China
3.Wenzhou Med Univ, Inst Biomed Informat, Sch Lab Med & Life Sci, Wenzhou 325000, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Anim
关键词： Thymosin beta4;Hair re-growth;Hair follicle;Wnt
期刊名称：MOLECULAR GENETICS AND GENOMICS （ 影响因子：3.291； 五年影响因子：3.257 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Although thymosin beta 4 (T beta 4) is known to play a role in hair growth, its mechanism of action is unclear. We examined the levels of key genes in a T beta 4 epidermal-specific over-expressing mouse model and T beta 4 global knockout mouse model to explore how T beta 4 affects hair growth. By depilation and histological examination of the skin, we confirmed the effect of T beta 4 on hair growth, the number of hair shafts and hair follicle (HF) structure. The mRNA and protein expression of several genes involved in hair growth were detected by real-time PCR and western blotting, respectively. Changes in the expression of beta-catenin and Lef-1, the two key molecules in the Wnt signaling pathway, were similar to the changes observed in T beta 4 expression. We also found that compared to the control mice, the mRNA and protein expression of MMP-2 and VEGF were increased in the T beta 4 over-expressing mice, while the level of E-cadherin (E-cad) remained the same. Further, in the T beta 4 global knockout mice, the mRNA and protein levels of MMP-2 and VEGF decreased dramatically and the level of E-cad was stable. Based on the above results, we believe that T beta 4 may regulate the levels of VEGF and MMP-2 via the Wnt/beta-catenin/Lef-1 signaling pathway to influence the growth of blood vessels around HFs and to activate cell migration. T beta 4 may have potential for the treatment of hair growth problems in adults, and its effects should be further confirmed in future studies.
- 相关文献
作者其他论文 更多>>
-
Knockdown of tyrosine hydroxylase gene affects larval survival, pupation and adult eclosion in Plagiodera versicolora
作者：Liu, Xiaolong;Wang, Xin;Zhang, Qi;Lu, Min;Ze, Longji;Zhang, Hainan
关键词：cuticle tanning; mortality;
Plagiodera versicolora ; RNA interference; tyrosine hydroxylase -
Biological delignification and anaerobic fermentation of wheat straw: A promising approach for sustainable utilization of crop straw bioresources
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Crop residues; Wheat straw; Lignin degradation; Anaerobic fermentation; Enzymatic hydrolysis; In vitro digestibility
-
Evaluation of growth stage and storage time on fermentation characteristics, microbial community structure, co-occurrence networks, and their functional shifts and pathogenic risk of fermented Italian ryegrass
作者：Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi;Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi
关键词：Growth stage; Fermentation product; Microbial community; Lolium multiflorum; Microbial risk
-
Effect of biological lignin depolymerization on rice straw enzymatic hydrolysis, anerobic fermentation characteristics and in vitro ruminal digestibility
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Rice straw; Lignin depolymerization; Ensiling; Enzymatic hydrolysis; In vitro digestibility
-
An evaluation of storage length on ensiling characteristics, bacterial community compositions, co-occurrence networks, and their functional shifts and pathogenic risk in high-moisture oat silage
作者：Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi;Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi
关键词：Oat; Ensiling; Silage; Fermentation quality; Bacterial community
-
Fermentation Profile, Bacterial Community Structure, Co-Occurrence Networks, and Their Predicted Functionality and Pathogenic Risk in High-Moisture Italian Ryegrass Silage
作者：Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi;Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi
关键词：Italian ryegrass; ensiling; silage; fermentation quality; bacterial community
-
GbCYP72A1 Improves Resistance to Verticillium Wilt via Multiple Signaling Pathways
作者：Xu, Jianwen;Zhao, Jun;Liu, Jianguang;Zhao, Liang;Xu, Peng;Xu, Zhenzhen;Guo, Qi;Xiao, Songhua;Dong, Chengguang;Wang, Xin;Ai, Nijiang;Feng, Guoli;Wang, Ningshan;Cheng, Junling;Wang, Yueping
关键词：biological stress; cotton; cytochrome P450; Verticillium dahliae; Verticillium wilt
